The co-repressor proteins SMRT and NCoR concentrate in specific subnuclear compartments and function with DNA-binding factors to inhibit transcription. To provide detailed mechanistic understanding of these activities, this study tested the hypothesis that functional interactions with transcription factors, such as the pituitary-gland-specific Pit-1 homeodomain protein, direct the subnuclear or...

MOTIVATION It has been recently suggested that atomic burials, as expressed by molecular central distances, contain sufficient information to determine the tertiary structure of small globular proteins. A possible approach to structural determination from sequence could therefore involve a sequence-to-burial intermediate prediction step whose accuracy, however, is theoretically limited by the m...

Introduction: Pit craters are circular to elliptical collapse features that commonly occur in alignments (chains) and that coalesce into troughs [1], [2], [3], [4], [5]. We have begun systematically mapping the regional distribution of pit chains in the western hemisphere of Mars using the Mars Orbiter Camera (MOC) data. Pit chains are most prominent in the Alba Patera region and along the Vall...

A cDNA encoding an Na+-Pi co-transporter, termed rat PiT-1, has now been isolated from rat parathyroid. Expression of rat PiT-1 in Xenopus oocytes revealed that it possesses Na+-dependent Pi co-transport activity. The amount of PiT-1 mRNA in the parathyroid of vitamin D-deficient rats was reduced compared with that in normal animals, and increased markedly after administration of 1,25-dihydroxy...

Prophet of Pit-1 (Prop1) is a transcription factor that regulates Pit-1 gene expression. Because Pit-1 regulates the differentiation of pituitary cells and the expressions of GH, prolactin and TSHbeta genes, Prop1 mutation results in combined pituitary hormone deficiency in humans. However, Prop1-binding sites in human Pit-1 gene and the mechanism leading to combined pituitary hormone deficienc...

Shelter staff and veterinarians routinely make subjective dog breed identification based on appearance, but their accuracy regarding pit bull-type breeds is unknown. The purpose of this study was to measure agreement among shelter staff in assigning pit bull-type breed designations to shelter dogs and to compare breed assignments with DNA breed signatures. In this prospective cross-sectional st...

Tests of Pavlovian-instrumental transfer (PIT) demonstrate that reward-predictive stimuli can exert a powerful motivational influence on the performance of instrumental actions. Recent evidence suggests that predictive stimuli produce this effect through either the general arousal (general PIT) or the specific predictions (outcome-specific PIT) produced by their association with reward. In two ...

This study offers initial research on Physically Interactive Technology (PIT). Findings of this research reveal how people made sense of PIT, how the ways people understand PIT reveal presence due to physical interaction, and how PIT challenges the definition of online interaction. Current and past literature on social presence theory and social cues theory provide a rationale for how “present”...

The Bruce Boyd site is an Early Woodland burial area on a sand knoll near Long Point, Lake Erie. Excavation uncovered several burials and offerings with cache blades, Meadowood points, trapezoidal gorgets, galena, copper beads, copper bracelets, iron pyrites and red ochre. The ceramics were cordmarked on both interior and exterior, some of them also showing punctates on the lip and exterior rim.