Familial combined pituitary hormone deficiency is a rare endocrine disorder. We describe growth patterns of four children (3 females and 1 male) from two families with combined pituitary hormone deficiency. These children received growth hormone at ages ranging from 14.5 years to 19 years. While all the female siblings reached their target height, the male sibling was much shorter than mid pare...

OBJECTIVE Cocaine- and amphetamine-regulated transcript (CART) is widely expressed in the rat brain, especially in the hypothalamic nuclei and in the anterior pituitary. The aim of this study was to evaluate the effects of CART on pituitary hormone release in pituitary cell culture. MATERIAL AND METHODS The pituitary hormone release from pituitary cell culture after CART administration was in...

A surgically removed pituitary adenomas, approximately 30-35% appear to be silent, unassociated with clinical or biochemical evidence of any anterior pituitary hormone excess (1, 2). However, with routine immunocytochemical staining of the pituitary tumor tissue, immunoreactive hormone material can be demonstrated in a substantial number of these seemingly nonfunctioning tumors (2). Clinically ...

Pure preparations of pituitary and hypothalamic hormones are needed mainly for (1) their chemical characterisation, which increases our understanding of their biochemistry and makes their synthesis possible; (2) replacement therapy, in which contamination with other pituitary hormones is undesirable; and (3) the development of specific diagnostic assays. Pituitary hormones were first isolated f...

INTRODUCTION Gamma Knife (GK) radiosurgery for pituitary adenomas can offer a means of tumor and biologic control with acceptable risk and low complication rates. METHODS Retrospective review of all the patients treated at our center with GK for pituitary adenomas from Nov 2003 to June 2011. RESULTS We treated a total of 86 patients. Ten were lost to follow-up. Mean follow was 32.8 months. ...