BACKGROUND Arformoterol tartrate (arformoterol, 15 μg bid) is a nebulized long-acting β2-agonist approved for maintenance treatment of COPD. METHODS This was a multicenter, double-blind, randomized, placebo-controlled study. Patients (aged ≥ 40 years with baseline FEV1 ≤ 65% predicted, FEV1 > 0.50 L, FEV1/FVC ≤ 70%, and ≥ 15 pack-year smoking history) received arformoterol (n = 420) or placeb...

BACKGROUND We assessed the efficacy of low-dose aripiprazole added to antidepressant therapy (ADT) in major depressive disorder (MDD) patients with inadequate response to prior ADT. METHODS As per the sequential parallel comparison design, 225 MDD subjects were randomized to adjunctive treatment with aripiprazole 2 mg/day or placebo across two 30-day phases, with a 2:3:3 randomization ratio t...

Abstract Background Benign prostatic hyperplasia (BPH) is the most common urologic disease among elderly men. The diagnosis of BPH usually driven by lower urinary tract symptoms (LUTS) that can significantly affect patients’ quality life. This phase II prospective, randomized double-blinded, placebo-controlled study aimed to determine efficacy and safety a novel whole tomato-based food suppleme...

Abstract Background Benign prostatic hyperplasia (BPH) is the most common urologic disease among elderly men. The diagnosis of BPH usually driven by lower urinary tract symptoms (LUTS) that can significantly affect patients’ quality life. This phase II prospective, randomized double-blinded, placebo-controlled study aimed to determine efficacy and safety a novel whole tomato-based food suppleme...

Background and aim: Chronic skin lesions are common late complications of sulfur mustard intoxication which would result in numerous complaints including pruritus, skin dryness and burn feeling. In chemical warfare injured veterans, pruritus is the most common complaint in chronic status with significant effects on patient's quality of life. This study has evaluated efficacy of topical ph...

Background Patients with chronic inflammatory diseases can experience significant fatigue, negatively impacting health-related quality-of-life. 1,2 Objectives This post-hoc analysis evaluated baseline fatigue severity among patients psoriasis and/or psoriatic arthritis (PsA) and the effect of guselkumab treatment on patient-reported fatigue. Methods VOYAGE-2 every 8 weeks (Q8W) versus placebo (...

Zusammenfassung Innovative therapeutische Ansätze zur Behandlung des Typ-2-Diabetes (T2D) sollten idealerweise sowohl Senkung glykierten Hämoglobins (HbA1c) als auch Gewichtsabnahme beitragen und eine überlegene Wirksamkeit gegenüber derzeit verfügbaren Behandlungsoptionen zeigen. Der Inkretinrezeptor-Agonist Tirzepatid (LY3298176) – entwickelt, um die Rezeptoren Glukose-abhängigen insulinotrop...

Placebo response in the clinical trial setting is poorly understood and alleged to be driven by statistical confounds, and its biological underpinnings are questioned. Here we identified and validated that clinical placebo response is predictable from resting-state functional magnetic-resonance-imaging (fMRI) brain connectivity. This also led to discovering a brain region predicting active drug...

objective: we conducted a double-blind, placebo-controlled study to determine the efficacy of an herbal sexual supplement (vigrx) on premature ejaculation (pe). method: a randomized double blind study was conducted on a fixed dose of herbal vigrx at roozbeh psychiatry hospital, tehran university of medical sciences. the sample consisted of 85 married patients diagnosed with primary pe according...

Abstract Background: As an inflammatory cytokine that can induce the repair of barrier tissue, IL-17 not only participates in anti-infection immune response, but also plays a key role some chronic diseases, including Ankylosing spondylitis (AS). Inhibition IL-17A reduce disease activity AS and joint damage. AK111 is humanized IgG1 monoclonal antibody against IL-17A. Methods: A total 120 patient...