OBJECTIVE The purpose of this study was to investigate the expression of the D6 decoy receptor that can bind chemokines and target them for degradation, resulting in inhibition of inflammation in placentas from preeclamptic and normal pregnancies. METHODS The current study was carried out in 35 pregnant women (23 patients with preeclampsia and 12 healthy, normotensive pregnant women) during t...

The placentas of ruminants and muroid rodents express prolactin (PRL)-related genes whereas the placentas of anthropoid primates express growth hormone (GH)-related genes. The evolution of placental expression is associated with accelerated evolution of the corresponding pituitary hormone and destabilization of conserved endocrine systems. In particular, placental hormones often evolve novel in...

It has been well documented that preeclampsia (PE) has a common etiological background, but little is known about its linkage at the molecular level.Non- coding RNAs are critical posttranscriptional regulators ofgene expression. This study was performed to determine whether PE is associated with alterations in placental non-coding RNAs expression. MicroRNA (miR)-155-5p and long non-coding RNA (...

Combined antiretroviral therapy has proven efficacy in decreasing vertical HIV transmission. However, endoplasmic reticulum stress is a known side effect of HIV protease inhibitors. We investigated endoplasmic reticulum stress in placentas of HIV-infected and uninfected mothers by PCR-based splicing analysis of the specific endoplasmic reticulum stress marker XBP1 in post-delivery placental sam...

Extracts from over 100 normal human placentas have been examined for RNA-directed DNA polymerase (DNA nucleotidyltransferase, EC 2.7.7.7) activity. More than 80% of these placentas contained this enzyme activity, which banded at a density of 1.15-1.17 g/ml in sucrose. After heat treatment, this enzyme activity was shifted in density to 1.22-1.24 g/ml. The enzymatic activity was greater with (rC...

Background/Aim: Preeclampsia (PE) complicates 2–8% of all pregnancies worldwide. Placental malperfusion and dysfunction are observed in PE. The supply glucose, the main energy substrate for fetus placenta, is regulated by placental expression activity specific glucose transporter proteins (GLUTs), primarily GLUT1. GLUT1 affected uteroplacental oxidative stress, which important components Very f...

In spite of a long and intensive search, human retroviruses have not yet been demonstrated unambiguously (for review see Pimentel 1979). The electron microscopic detection of retrovirus particles in human term placentas by Kalter and others (Kalter et al. 1973; Vernon et al. 1974) represents at present the most convincing piece of evidence that human oncornaviruses may exist. As our attempts to...

Placental development requires extensive angiogenesis and the invasion of the maternal decidua by the trophoblasts. Adequate and organized interaction of vascular endothelial growth factors (VEGF), placenta growth factors (PlGF), and their receptors are essential for a normal development and function of the placenta. In this study, we evaluated the expressions of PlGFs and their receptors, mRNA...

OBJECTIVE To determine the prevalence of placental pathology among low birthweight infants delivered at Srinagarind Hospital. MATERIAL AND METHOD Descriptive study of 114 placentas from infants weighing between 500 and 2,499 grams delivered between June 2002 and June 2004 in the labour room, Srinagarind Hospital. Placentas from low birthweight infants were examined by a perinatal pathologist ...

An immunohistological survey of 28 full-term human placentas has demonstrated deposits of IgG, beta1C, beta1E, and fibrinogen/fibrin in areas of fibrinoid necrosis and on the trophoblast basement membrane in approximately 35% of placental villi. Traces of IgM were detected at similar sites in 18 of 28 full-term placentas. In 11 specimens of immature placentas (10-18 wk gestation) traces of IgG ...