background: momordica charantia (m. charantia) seed has been supposed to have an antifertility property but mechanisms underlying the infertility effect have not been investigated. objective: we investigated the antifertility effect of m. charantia ethanol seed extracts on reproductive toxicology and seminal and plasma testosterone in male wistar rats. materials and methods: the control group (...

background : methamphetamine (ma) is an illegal amphetamine-like which stimulate the central nervous system. in recent years, ma has been widely abused worldwide. previous studies have suggested that oxidative stress (os) plays an important role in ma-induced toxicity. from this view, antioxidant therapy could be considered as a potential drug therapy in ma abusers. therefore, the objective of ...

normal 0 false false false en-us x-none ar-sa dear editor with interest, i read the article by khalilian et al. 1 recently published in your journal. we know that in adult patients, atrial natriuretic peptides (anp) and brainnatriuretic peptides (bnp) have been used for diagnosis, monitoring of treatment effects, and estimating the prognosis of systolic and diastolic heart failure. 2 furthermor...

Medicinal plants have attracted global attention due to their high levels of antioxidant components for prohibiting or improving various diseases including brain and memory disorders. This study was designed to investigate if the antioxidant effect of Sidr (Zizyphusspina-christi) extract can help to improve the scopolamine induced impairment of memory in Wistar rats. Animals were randomly...

The present study was conducted to find the effect of three heavy metals, Ag, Hg and Pb on the expression level of a gene encoding plasma membrane H+-ATPase in Aeluropus littoralis. The experiment was laid out in a completely random design with three replications. The expression of the main gene was normalized to the expression of the housekeeping gene actin. Two 259 and 187 bp fragments were a...

The pharmacokinetics of levofloxacin following its single intramuscular administration (3 mg/kg) was investigated in six male buffalo calves. Peak plasma level of 2.95 ± 0.13μg/ml was observed at 1 h and the drug level above MIC90  in plasma was detected up to 12 h of administration. The bioavailability was 68.1 ± 5.4% and levofloxacin was bound to the plasma proteins to the extent of 19.1 ± 1....