Flow cytometric detection of platelet surface-associated IgG (PSAIgG) can be used to determine whether immunologic factors are contributing to thrombocytopenia in dogs. In vitro alterations in platelet activation and morphology, however, could impact the results of this test. The purpose of this study was to determine whether the PSAIgG test for immune-mediated thrombocytopenia was valid on who...

  I read with interest Dr. Yazdani's reply about the article entitled “administration of magnesium sulfate to women with premature labor: The effect on bleeding time”.1 In my review of hematology references, I could not find any reference for determining hemoglobin (Hb) sooner than 24 hrs and Dr. Yazdani had not cited any reference either. However, about the influence of Hb on homeostasis, ther...

INTRODUCTION With prolonged storage times, cell membranes of red blood cells (RBCs) undergo morphologic and biochemical changes, termed 'RBC storage lesions'. Storage lesions may promote inflammation and thrombophilia when transfused. In trauma patients, RBC transfusion was an independent risk factor for deep vein thrombosis (DVT), specifically when RBC units were stored > 21 days or when 5 or ...

The mean platelet component (MPC) parameter calculated by the ADVIA blood cell analyzers provides direct information on density, or granularity, of platelets and could become a useful biomarker to detect in vivo platelet activation. Unfortunately, it is largely affected by time and storage conditions in standard anticoagulants based on EDTA. The present study was designed to improve the stabili...

Platelet transfusion therapy has played an important role in the management of patients [4]. Today, a variety of methods for the preparation of platelets for transfusion are available ,which may be due to different processing systems such as apheresis ,buffy coat and platelet rich plasma platelet concentres methods [5,6]. Processing and storage may affect both platelet quality and function and ...

The mouse pigment mutant pale ear, ep/ep, which has a defect in kidney lysosomal enzyme secretion, had prolonged bleeding on experimental injury. Platelet counts and platelet protein did not differ from normal. There was, however, a deficiency in the platelet dense granule contents, serotonin, ATP, and ADP. Furthermore, a marked reduction of platelet dense granules was observed by electron micr...