نتایج جستجو برای: plga drug delivery system
تعداد نتایج: 2853566 فیلتر نتایج به سال:
One of the challenges nanotechnology is to improve efficacy treatments for diseases, in order reduce morbidity and mortality rates. Following this line study, we made a nanoparticle formulation with small size, uniform surfaces, satisfactory encapsulation coefficient as target colorectal cancer cells. The results binding uptake prove that using system folic acid works: Using system, cytotoxicit...
Poly(lactic-co-glycolic acid) (PLGA) is the most widely used biomaterial for microencapsulation and prolonged delivery of therapeutic drugs, proteins and antigens. PLGA has excellent biodegradability and biocompatibility and is generally recognized as safe by international regulatory agencies including the United States Food and Drug Administration and the European Medicines Agency. The physico...
Open vascular reconstructions frequently fail due to the development of recurrent disease or intimal hyperplasia (IH). This paper reports a novel drug delivery method using a rapamycin-loaded poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs)/pluronic gel system that can be applied periadventitially around the carotid artery immediately following the open surgery. In vitro studies revealed t...
The purpose of this study is to prepare cationic nanoparticles (NPs) by coating chitosan (CS) on the surface of PLGA NPs and evaluated laser thrombolysis capabilities and photomechanical drug delivery in a blood clot. The tPA encapsulated PLGA and PLGA/ CS nanoparticles were fabricated via the W/O/W double emulsion solvent evaporation surface coating method. The characteristics of NPs are deter...
Poly(D,L-lactic-co-glycolic acid) (PLGA) microspheres were prepared by an oil/water emulsion solvent evaporation method to use as an injectable microcarrier for cell delivery. Three different kinds of PLGA microspheres having hydrophobic, negatively charged, and positively charged surfaces were prepared. Hydrophobic and negatively charged PLGA microspheres were prepared by using terminally capp...
BACKGROUND Peptide based vaccines may suffer from limited stability and inefficient delivery to professional antigen-presenting cells (APCs), such as dendritic cells (DCs). In order to overcome such limitations, several types of biodegradable nanoparticles (NPs) have been developed as carrier system for antigens. The present study describes for the first time the extensive biological characteri...
It is hypothesized that the bioavailability of αT (alphatocopherol), an antioxidant, can be improved when delivered by poly(lactic-co-glycolic) acid (PLGA) nanopar‐ ticles (NPs) and chitosan covered PLGA nanoparticles (PLGA-Chi NPs), and that the mucoadhesive properties of chitosan may enhance absorption of αT. PLGA and PLGAChi NPs were characterized by measuring entrapment efficiency, size, po...
Bone is a favorable microenvironment for tumor growth and a frequent destination for metastatic cancer cells. Targeting cancers within the bone marrow remains a crucial oncologic challenge due to issues of drug availability and microenvironment-induced resistance. Herein, we engineered bone-homing polymeric nanoparticles (NPs) for spatiotemporally controlled delivery of therapeutics to bone, wh...
The huperzine A-phospholipid complex loaded biodegradable thermosensitive PLGA-PEG-PLGA polymer gel was studied as injectable implant system for controlled release of huperzine-A (HA). First, HA molecules were successfully incorporated into the soybean phosphatidylcholine (SP) molecules to form the huperzine-A-soybean phosphatidylcholine complexes (HA-SPC), which was proved by FT-IR, DSC, XRD, ...
Nanopartikel poly (lactic-co-glycolic acid) (PLGA) adalah salah satu nanopartikel polimer biodegradable yang paling efektif dalam sistem penghantaran obat. Penelitian ini dilakukan untuk mengkaji perkembangan penelitian PLGA obat melalui pendekatan bibliometrik dengan analisis pemetaan menggunakan VOSviewer. Data artikel diperoleh dari database Google Scholar software Publish or Perish. Kata ku...
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