نتایج جستجو برای: plumbagin
تعداد نتایج: 378 فیلتر نتایج به سال:
Over the past few decades there has been much interest in natural materials as sources of new antibacterial agents. Different extracts from traditional medicinal plants have been tested. Many reports show the effectiveness of traditional herbs against microorganisms; as a result, plants have become one of the bases of modern medicine (Evans et al., 2002). Plants have given the Western pharmacop...
Tuberculosis has been a serious public health problem for a long time. With the advent of anti-tubercular antibiotics in the late 1940s, the battle against tuberculosis seemed to have been won but the multi-drug resistance; re-infection and latent infection have become the major cause of concern for the treatment of tuberculosis all over the world. In the present study derivatives of Plumbagin,...
Like cancer, pulmonary arterial hypertension (PAH) is characterised by a pro-proliferative and anti-apoptotic phenotype. In PAH, pulmonary artery smooth muscle cell (PASMC) proliferation is enhanced and apoptosis suppressed. The sustainability of this phenotype requires the activation of pro-survival transcription factors, such as signal transducer and activator of transcription (STAT)3 and nuc...
Resistant cancer phenotype is a key obstacle in the successful therapy of prostate cancer. The primary aim of our study was to explore resistance mechanisms in the advanced type of prostate cancer cells (PC-3) and to clarify the role of autophagy in these processes. We performed time-lapse experiment (48 hours) with ROS generating plumbagin by using multimodal holographic microscope. Furthermor...
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