conclusions pmf-dependent efflux mechanism appears to play an important role in the mdr phenotype of a. baumannii clinical strains. background multidrug-resistant (mdr) strains of acinetobacter baumannii have been increasingly reported as a major cause of nosocomial infections, and have created major therapeutic problems worldwide. objectives the aim of the present study was to evaluate the rol...

BACKGROUND Essential Thrombocythemia (ET) and Primary Myelofibrosis (PMF) are Chronic Myeloproliferative Neoplasms (MPN) characterized by clonal myeloproliferation/myeloaccumulation without cell maturation impairment. The JAK2 V617F mutation and PRV1 gene overexpression may contribute to MPN physiopathology. We hypothesized that deregulation of the apoptotic machinery may also play a role in th...

Polymethoxyflavones (PMF) are a group of flavonoids isolated from citrus peels that show crystallization properties. The purpose this study was to investigate the impact PMF on microstructure, stability and bioaccessibility PMF-loaded high internal phase emulsions (HIPE) stabilized using protein polysaccharide complexes. To improve loading capacity PMF, HIPE biopolymeric complexes developed as ...

Primary myelofibrosis (PMF) is a clonal myeloproliferative neoplasm whose severity and treatment complexity are attributed to the presence of bone marrow (BM) fibrosis and alterations of stroma impairing the production of normal blood cells. Despite the recently discovered mutations including the JAK2V617F mutation in about half of patients, the primitive event responsible for the clonal prolif...

The potential of mean force (PMF) calculation in single molecule manipulation experiments performed via the steered molecular dynamics (SMD) technique is a computationally very demanding task because the analyzed system has to be perturbed very slowly to be kept close to equilibrium. Faster perturbations, far from equilibrium, increase dissipation and move the average work away from the underly...

We investigate the analytical representation of potentials of mean force (pmf) using the Morse/long-range (MLR) potential approach. The MLR method had previously been used to represent potential energy surfaces, and we assess its validity for representing free-energies. The advantage of the approach is that the potential of mean force data only needs to be calculated in the short to medium rang...

We investigated noninvasive procedures by hybrid imaging to assess the sites of active or inactive hematopoiesis in patients with primary myelofibrosis (PMF). To this end, we used two radionuclides, technetium 99m ((99m) Tc) and indium 111-chloride ((111) In-Cl3 ), coupled with single-photon emission tomography/computed tomography (SPECT/CT). We studied five patients with PMF and one with secon...

One hundred and twenty-five men who were identified in 1968 as having the simple pneumoconiosis of coalworkers were re-examined nine years later when their mean age was 59.6 years. On both occasions the lung function and response to exercise were assessed. There was no evidence for progression of simple pneumoconiosis between the surveys, but 14 had developed small irregular opacities on their ...

We study conditions for the detection of an N -length iid sequence with unknown pmf p1, among M N -length iid sequences with unknown pmf p0. We show how the quantity M2−N D(p1||p0) determines the asymptotic probability of error.

The molecular pathogenesis underlying the primary myelofibrosis (PMF) progression to acute myeloid leukemia (AML) is still not well defined. The involvement of microRNA (miRNA) is actually helping to shed light on an important issue in the occurrence of myeloproliferative neoplasms (MPNs). However, the role of intronic miRNA, derived from the intron regions of gene transcripts, has never been r...