نتایج جستجو برای: pml

تعداد نتایج: 3358  

Journal: :Journal of neurology, neurosurgery, and psychiatry 1999
L Monno G B Zimatore M Di Stefano A Appice P Livrea G Angarano

OBJECTIVES To confirm reduced human immunodeficiency virus type-1 (HIV-1) burden in the CSF of patients with progressive multifocal leukoencephalopathy (PML) and to verify whether this viral load coincides with the absence of inflammatory changes in the CSF. METHODS Paired CSF and plasma samples from 17 patients with PML, 26 with non-PML cerebral opportunistic infections, nine with HIV-1 leuk...

2016
Christian E. Lamm Myriam Scherer Nina Reuter Bushra Amin Thomas Stamminger Uwe Sonnewald

Eukaryotic nuclei are subdivided into subnuclear structures. Among the most prominent of these structures are the nucleolus and the PML nuclear bodies (PML-NBs). PML-NBs are spherical multiprotein aggregates of varying size localized in the interchromosomal area. PML-NB formation is dependent on the presence of the promyelocytic leukemia protein (PML) as well as on post-translational modificati...

Journal: :Neurology 2011
I L Tan J C McArthur D B Clifford E O Major A Nath

OBJECTIVE To study the outcome of patients with multiple sclerosis (MS) and with natalizumab-associated progressive multifocal leukoencephalopathy (PML) and immune reconstitution inflammatory syndrome (IRIS). METHODS MedWatch reports from Biogen-Idec (manufacturer of natalizumab, Tysabri(®)) were reviewed which comprised all 42 cases of natalizumab-related PML cases since its reintroduction u...

2012
JAMES H. BRAMBLE JOSEPH E. PASCIAK

We consider the application of a perfectly matched layer (PML) technique applied in Cartesian geometry to approximate solutions of the acoustic scattering problem in the frequency domain. The PML is viewed as a complex coordinate shift (“stretching”) and leads to a variable complex coefficient equation for the acoustic wave posed on an infinite domain, the complement of the bounded scatterer. T...

Journal: :Blood 1997
D Grimwade P Gorman E Duprez K Howe S Langabeer F Oliver H Walker D Culligan J Waters M Pomfret A Goldstone A Burnett P Freemont D Sheer E Solomon

Acute promyelocytic leukemia (APL) is typified by the reciprocal translocation, t(15; 17)(q22; q21), leading to the formation of PML-RARalpha and RARalpha-PML fusion genes. We have characterized 7 cases of morphologic APL found to lack the t(15; 17) on conventional cytogenetic assessment. In 6 of 7 cases, cryptic PML-RARalpha rearrangements were identified by reverse transcriptase-polymerase ch...

2013
Natalia Martin-Martin James D. Sutherland Arkaitz Carracedo

Since the discovery of Promyelocytic leukemia (PML), this protein has been associated with the pathogenesis of several hematopoietic malignancies and solid tumors. PML was first identified as part of a fusion oncoprotein, PML-RARα, responsible for the development of acute promyelocytic leukemia (APL) (1–4). The PML-RARα fusion protein not only alters PML function but also represses transcriptio...

2014
Xi Liu Hao Yuan Laurent Peres Saijuan Chen Zhu Chen Hugues de The Jun Zhou Jun Zhu

PML/RARA is the oncoprotein driving acute promyelocytic leukemia (APL). It suppresses genes expression by recruitment of a number of transcriptional repressors, resulting in differentiation block and malignant transformation of hematopoietic cells. Here, we found that mice primary hematopoietic progenitor cells (HPCs), transduced by DNA-binding-defective PML/RARA mutants, were deficient in colo...

2013
Guoxiang Jin Ying-Jan Wang Hui-Kuan Lin

The tumor suppressor promyelocytic leukemia protein (PML) is located primarily in the nucleus, where it is the scaffold component of the PML nuclear bodies (PML-NBs). PML-NBs regulate multiple cellular functions, such as apoptosis, senescence, DNA damage response, and resistance to viral infection. Despite its nuclear localization, a small portion of PML has been identified in the cytoplasm. Th...

Journal: :Blood 1996
J V Raelson C Nervi A Rosenauer L Benedetti Y Monczak M Pearson P G Pelicci W H Miller

Acute promyelocytic leukemia (APL) is characterized by the translocation, t(15;17) and the expression of a PML/RAR alpha fusion protein that is diagnostic of the disease. There is evidence that PML/RAR alpha protein acts as a dominant negative inhibitor of normal retinoid receptor function and myeloid differentiation. We now show that the PML/RAR alpha fusion product is directly downregulated i...

2013
Lisa Ivanschitz Hugues De Thé Morgane Le Bras

Since its discovery, 25 years ago, promyelocytic leukemia (PML) has been an enigma. Implicated in the oncogenic PML/RARA fusion, forming elusive intranuclear domains, triggering cell death or senescence, controlled by and perhaps controlling SUMOylation… there are multiple PML-related issues. Here we review the reciprocal interactions between PML, senescence, and SUMOylation, notably in the con...

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