Using the bacterial K+ channel KcsA as a template, we constructed models of the pore region of the cardiac ryanodine receptor channel (RyR2) monomer and tetramer. Physicochemical characteristics of the RyR2 model monomer were compared with the template, including homology, predicted secondary structure, surface area, hydrophobicity, and electrostatic potential. Values were comparable with those...

2-(2,4-Dihydroxyphenylo)-5,6-dichlorobenzthiazole (dHBBT) is a new drug from the group of chemical compounds characterized by documented antifungal, antibacterial, cytostatic as well as antitumour activity. Despite general knowledge regarding pharmacological importance of dHBBT its interaction to biomembranes has not been investigated. In this work, we present the electronic absorption spectros...

Novel supramolecular side-chain banana-shaped liquid crystalline (LC) polymer complexes AmBn-N bearing various (m/n) molar ratios of hydrogenand covalent-bonded bent-core components were acquired by the free radical polymerization, where the hydrogen-bonded (H-bonded) structures were executed via mixing equimolar portions of proton donor (H-donor) polymers AmBn (homopolymers/ copolymers) and py...

4-t-Butylcatechol (TBC) is an antioxidant used primarily as a polymerization inhibitor for reactive monomers. Annual production and use of TBC in the United States is approximately 1.5 million pounds. The absorption, tissue distribution, metabolism, and excretion of [(14)C]TBC, labeled in the methine carbon, was investigated in male Fischer 344 rats and B6C3F(1) mice after i.v., oral, and derma...

In this paper, we first give a characterization of sub-topical functions with respect to their lower level sets and epigraph. Next, by using two different classes of elementary functions, we present a characterization of sub-topical functions with respect to their polar functions, and investigate the relation between polar functions and support sets of this class of functions. Finally, we obtai...

Three aromatic oligoamides have been prepared that have alternating 1,6-diaminopyridine and 1,6-pyridinedicarboxylic acid units at the center of the sequence and two 8-amino-2-quinolinecarboxylic acid units at each extremity. The three oligomers differ in the number--3, 5, or 7-of pyridine units in the sequence. They were designed to adopt helically folded conformations in solution and in the s...

Polyolefins are of vast economic importance, which is reflected by an annual production of more than 70 million tons of polyethylene and polypropylene. While the major portion of these materials is produced with Zieglerand chromium-based catalysts, the older free-radical process that affords low-density polyethylene (LDPE) has maintained its significance.[1] Despite the necessity of working at ...

We have examined the rate-limiting steps involved in bile acid absorption across the unstirred water layer and lipid cell membrane of the jejunal mucosa. Uptake of the polar bile acid taurocholate is limited solely by the cell membrane since this compound permeates the unstirred water layer more rapidly than the lipid cell membrane and stirring does not enhance uptake. With less polar bile acid...

Polymers bearing polar functionalities are important materials, since they exhibit beneficial properties with respect to adhesion, paint/printability and surface properties. Commercial synthesis of these materials is mainly based on radical processes, which (so far) only allow poor control over the stereochemistry of the resulting polymers. 2 ] Stereo-controlled polymerisation generally require...