A Correction to this paper has been published: https://doi.org/10.1038/s41928-021-00571-3.

Introduction: Periurethral injection with polyacrylamide hydrogel (PAHG, Bulkamid®) is a minimally invasive treatment option to be considered for women stress urinary incontinence. The manufacturer recommends injecting between 1.5 ml and 2 periurethrally. This study aims evaluate the long-term efficacy of PAHG, determine whether there correlation volume PAHG injected outcome in terms symptoms. ...

Abstract Augmentation mammoplasty using hydrogel fillers such as polyacrylamide gel (PAAG) or Aquafilling® has been performed commonly in some countries an alternative to breast augmentation with saline silicone implants. However, the safety of this procedure remains controversial, and many complications associated use large-volume injection have reported recent years. We present case a 33-year...

The human skin, an important sensory organ, responds sensitively to external stimuli under various harsh conditions. However, the simultaneous achievement of mechanical/thermal sensitivity and extreme environmental tolerance remains enormous challenge for skin-like hydrogel-based sensors. In this study, a novel skin-inspired hydrogel–elastomer hybrid with sandwich structure strong interfacial b...

Substrate rigidity has been recognized as an important property that affects cellular physiology and functions. While the phenomenon has been well recognized, understanding the underlying mechanism may be greatly facilitated by creating a microenvironment with designed rigidity patterns. This chapter describes in detail an optimized method for preparing substrates with micropatterned rigidity, ...

Abstract Double-network (DN) hydrogels, consisting of two contrasting and interpenetrating polymer networks, are considered as perhaps the toughest soft-wet materials. Current knowledge DN gels from synthesis methods to toughening mechanisms almost exclusively comes chemically-linked hydrogels by experiments. Molecular modeling simulations inhomogeneous structure in have proved be extremely cha...