Temperature sensitive Pluronic (Plu) and pH-sensitive polyacrylic acid (PAA) were successfully mixed in different ratios to form in situ gelling formulations for colon cancer therapy. The major formulations were prepared as the liquid and solid suppository dosage forms. Epirubicin (Epi) was chosen as a model anticancer drug. In vitro characterization and in vivo pharmacokinetics and therapeutic...

An increasing number of promising applications for future technology is arising from size constraints in nanoparticles (NPs) and from the chemical manipulation of their surfaces. In this work, we analyse the finite-size and surface effects on polyacrylic acid-coated Fe(3)O(4) NPs and oleic acid-coated gamma-Fe(2)O(3) NPs by studying their magnetization curves at different temperatures. The meas...

Synthesized graft copolymers of chloroprene rubber with acrylic acid. A mixture benzene and dimethylformamide was used as a solvent, potassium persulfate polymerization initiator. Based on the dependence copolymerization rate concentrations components temperature, order reaction in terms concentration acid (2.0), (1.2) activation energy process (24.4 kJ/mole) were determined. The degree graftin...

Solubility parameter-dependent drug releasing property is essential in practical drug delivery systems (DDS), and how to combine magnetic nanoparticles(NPs) and suitable polymer coating towards DDS is always a crucial and valuable challenge in biomedical application. Herein, a controllable drug delivery model with a surface having a chemically tunable solubility parameter is presented using hol...

This study describes a polymer potentially used as vaccine adjuvant. We first synthesized novel polyacrylic acid modified by perfluorinated butanol—a bioactive compound that is biocompatible. The main aim was to functionalize the fluorine. functionalization could offer permanent graft an esterification reaction. chemical structure of has been characterized hydrogen nuclear magnetic resonance sp...