P LASMA HAPTOGLOBIN ( Hp ) is a well-characterized a2-glycoprotein which possesses the ability to bind hemoglobin ( Hb ), forming the haptoglobin-hemoglobin ( Hp-Hb ) complex.1 Under physiologic conditions, it is estimated that 20-40 per cent of the HP catabolized daily is degraded via complex formation with hemoglobin released during normal intravascular hemolysis.2’3 The hemoglobin thus made ...

Thromboembolic events represent the main cause of morbidity and mortality in patients with polycythemia vera. Leukocytosis has been identified as an important risk factor for development vascular thrombosis. A 47-year-old woman vera presented pain swelling her right calf. She was scheduled to receive anagrelide which effective on thrombocytosis, but leukocytosis persisted. diagnosed thrombosis ...

Immature platelets (IPFs), which are hemostatically more active than mature platelets, have been found elevated in essential thrombocythemia and polycythemia vera, 2 myeloproliferative neoplasms (MPN) characterized by an increased risk of thrombosis. It is not known whether the IPF levels are influenced by pathogenetic factors, including JAK2V617F mutational status, or by treatment regimen. To ...

The effects of primary and secondary polycythemia on circulatory and ventilatory events have been the center of much investigation. There has, however, been sharp disagreement about the clinical merit of phlebotomy in cases of secondary polycythemia. Howarth, et al.' and Lewis, et al.,' among others, have concluded, although for somewhat different reasons, that therapeutic phlebotomy is detrime...

Twenty-seven patients with p. vera and adverse hematologic effects were whose proliferative disease required the infrequent. To date one patient has desuppression of bone marrow function veloped refractory anemia and evidence were treated with melphalan for periods of myelofibrosis. Four patients have deof 20 to 72 months. The response was veloped acute leukemia but none of these rated as good ...

Thrombocytosis is a commonly encountered clinical scenario, with a large proportion of cases discovered incidentally. The differential diagnosis for thrombocytosis is broad and the diagnostic process can be challenging. Thrombocytosis can be spurious, attributed to a reactive process or due to clonal disorder. This distinction is important as it carries implications for evaluation, prognosis, a...

We investigated the pathogenesis of isolated erythrocytosis of 14 yr duration in a 28-yr-old man. The increase in red cell mass was attributed to increased erythropoietin production. An extensive search for recognized causes of secondary erythrocytosis was unrevealing. Family members were found to be hematologically normal. After reduction of the circulating red cell mass by 20%, erythropoietin...

To observe the effect of the new World Health Organization (WHO) criteria on the incidence of myeloproliferative neoplasms, we performed a retrospective study of a population-based registry in the Côte d'Or area, France, from 1980 to 2007. A total of 524 myeloproliferative neoplasms were registered for the 1980-2007 period, including 135 polycythemia vera, 308 essential thrombocythemia and 81 i...

Recently, a Jak2V617F mutation has been described in the vast majority of patients with polycythemia vera (PV) as well as in subsets of patients with essential thrombocythemia (ET) and idiopathic myelofibrosis (IMF). The question arises whether this mutation is observed in those patients with ET and IMF who have also displayed previously described molecular markers, notably the ability to form ...