نتایج جستجو برای: polymorphism carrier detection
تعداد نتایج: 735034 فیلتر نتایج به سال:
background: cytochrome p450 2c19 (cyp2c19) is important in metabolism of wide range of drugs. cyp2c19*17 is a novel variant allele which increases gene transcription and therefore results in ultra-rapid metabolizer phenotype (urm). distribution of this variant allele has not been well studied worldwide. the aim of present study was to investigate allele and genotype frequencies of cyp2c19*17 in...
BACKGROUND The recommendation for population- based cystic fibrosis (CF) carrier screening by the American College of Medical Genetics for the 25 most prevalent mutations and 6 polymorphisms in the CF transmembrane regulatory gene has greatly increased clinical laboratory test volumes. We describe the development and technical validation of a DNA chip in a 96-well format to allow for high-throu...
Peroxisome proliferator-activated receptor-γ (PPAR-γ) is a ligand-binding nuclear receptor, and its activation plays a prominent role in regulating the inflammatory response. Therefore, PPAR-γ has been suggested as a candidate gene for sepsis. In the present study, we investigated the association between the Pro12Ala polymorphism of PPAR-γ and sepsis in a Han Chinese population. A total of 308 ...
Sixty eight adult ewes of Zel sheep breed were screened with forced PCR RFLP method for the detection of the FecB gene and its effects on litter size. Genomic DNA was extracted from the blood of 68 Zel matured ewes with litter size varied from 1 to 2 lambs per ewe lambing. Digestion of the FecB gene (190 base pairs) with AvaII restriction enzyme resulted in none carrier 190 bp band wild type in...
Initially, psychometric functions were measured for the detection of amplitude modulation (AM) or frequency modulation (FM), using a two-alternative forced-choice (2AFC) task. Carrier frequencies were 125, 1000, and 6000 Hz, and modulation rates were 2, 5, and 10 Hz. For the two lower carrier frequencies, FM detection tended to be best at the lowest modulation rate while AM detection was best a...
evaluation of p53 codon 72 polymorphism in adenocarcinoma of the colon and rectum in guilan province
background : colorectal cancer is the second cause of mortality in developed countries. the p53gene and some of it's polymorphisms are among the causes for cancer development.the purpose of this study is to evaluate the relationship between the p53 codon 72 polymorphism in colorectal adenocarcinoma specimens compared with controls. materials and methods : we performed a case-control study among...
Nowadays viruses use polymorphic techniques to mutate their code on each replication, thus evading detection by antiviruses. However detection by emulation can defeat simple polymorphism: thus metamorphic techniques are used which thoroughly change the viral code, even after decryption. We briefly detail this evolution of virus protection techniques against detection and then study the METAPHOR...
Background and Aim: Cytokines are believed to play an important role in the regulation of cellular immune response in hepatitis B virus infection. Interleukin 10 is a member of cytokine family. The overall expression of these molecules is mainly controlled by single nucleotide polymorphisms at specific sites on the promoter region of the Interleukin 10 gene. The aim of this study was to a...
Nowadays viruses use polymorphic techniques to mutate their code on each replication, thus evading detection by antiviruses. However detection by emulation can defeat simple polymorphism: thus metamorphic techniques are used which thoroughly change the viral code, even after decryption. We briefly detail this evolution of virus protection techniques against detection and then study the METAPHOR...
The effect of temporal asymmetry on amplitude modulation detection was studied using sawtooth modulators with rising (ramped) or falling (damped) temporal envelopes within each period of modulation. For pure-tone carriers, damped modulation was more detectable than ramped modulation for a 5-kHz carrier (by a threshold difference of 3.2 dB on average) but not for a 1-kHz carrier. The threshold d...
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