Differentiation refers to the ability of cancer cells to revert to their normal counterparts, and its induction represents an important noncytotoxic therapy for leukemia, and also breast, prostate, and other solid malignancies. Flavonoids are a group of differentiation-inducing chemicals with a potentially lower toxicology profile than retinoids. Flavonoid-rich polyphenol fractions from the pom...

Objective(s): The aim of this study is to determine the therapeutic effects of pomegranate seed oil, which is a powerful antioxidant and anti-inflammatory agent, on ovarian-ischemia and reperfusion injury in rats.Materials and Methods: Fifty-six  female albino Wistar rats were divided into 7 equal groups. Group 1; Sham Operation, Group 2; Ischemia, Group 3; Ischemia + Reperfusion, Group 4; Isch...

Angiogenesis is critical to tumor growth and is stimulated by tissue hypoxia due to poor oxygen delivery. In turn, cellular hypoxia leads to angiogenesis via the induction of hypoxia-inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) at a cellular level. Pomegranate juice and extracts, which are rich sources of ellagitannins, have been shown to have chemopreventi...

Methanolic and aqueous extract of Pomegranate rind, seed and pith was evaluated for its antimicrobial activity against selected oral microorganisms like Staphylococcus aureus, Staphylococcus epidermis, Klebsiella pneumonia, Pseudomonas aeuriginosa and Candida albicans. The oral pathogens were cultured in Mueller-hinton media and then paper disks containing the extracts at concentration of 4μg/m...

The pomegranate (Punica granatum L.) is an important medicinal plant. It has been reported that phenolic compounds contained in the flowers have antioxidant potential. The objective was to determine the concentration of total phenolics and antioxidant capacity of three selections of pomegranate flower dried under different conditions. The highest phenolic content and antioxidant capacity was ob...

Pomegranate-derived polyphenols are expected to prevent life-style related diseases. In this study, we evaluated the ability of 8 pomegranate-derived polyphenols, along with other polyphenols, to augment SIRT3, a mammalian SIR2 homolog localized in mitochondria. We established a system for screening foods/food ingredients that augment the SIRT3 promoter in Caco-2 cells and identified 3 SIRT3-au...

Pomegranate (Punica granatum L.) is a nutrient dense food rich in beneficial phytochemicals. The aim of this study is to investigate and to determine antioxidant contents from local and highly consumed pomegranate variety called ‘Gabsi’. Peels, seeds, leaves and flowers were used to quantify total polyphenols, flavonoids, anthocyanins and hydrolysable tannins. Antioxidants contents were as foll...

Memory dysfunction is a common complaint following heart surgery and may be related to a diffuse ischemic state induced by microemboli dislodged during the procedure. Ischemia can induce damage by a number of mechanisms, including oxidative stress. Because pomegranates contain a variety of polyphenols with antioxidant and other potentially beneficial effects, we tested whether supplementation w...