BACKGROUND Management of women with reduced ovarian reserve or poor ovarian response (POR) to stimulation is one of the major challenges in reproductive medicine. The primary causes of POR remain elusive and oxidative stress was proposed as one of the important contributors. It has been suggested that focus on the specific subpopulations within heterogeneous group of poor responders could assis...

Ovarian cancer is a common and complex malignancy with poor prognostic outcome. Most women ovarian are diagnosed advanced stage disease due to lack of effective detection strategies in the early stage. Traditional treatment cytoreductive surgery platinum-based combination chemotherapy has not significantly improved prognosis 5-year survival rates still extremely poor. Therefore, novel needed im...

OBJECTIVE To evaluate recovery of endocrine function and fertility after transplantation and vitrification of whole ovaries. DESIGN Animal study. SETTING Lyon Veterinary School, France. ANIMAL(S) Ewes. INTERVENTION(S) In group 1 (n = 5), the left ovary was removed with its vascular pedicle and was transplanted onto the contralateral pedicle. In group 2 (n = 5), the left ovary with its p...

In recent years, advances in the diagnosis and treatment of childhood, adolescent and adult cancer have significantly improved the survival rate and life expectancy of cancer patients. However, chemotherapy and radiotherapy treatments are gonadotoxic and may induce the loss of ovarian function and fertility with consequent premature ovarian failure (POF). A number of factors determine the level...

Purpose: To elucidate molecular pathways contributing to metastatic cancer progression and poor clinical outcome in serous ovarian cancer. Experimental Design: Poor survival signatures from three different serous ovarian cancer datasets were compared and a common set of genes was identified. The predictive value of this gene signature was validated in independent datasets. The expression of the...

OBJECTIVE This study was to explore the role of EFEMP1 in ovarian tumor progression and its relationship with prognosis of ovarian carcinoma. METHODS EFEMP1 mRNA and protein expressions in normal ovarian tissue, ovarian tumor, high invasive subclones and low invasive subclones were evaluated by immunohistochemistry and real time RT-PCR. Serum EFEMP1 levels in patients with ovarian tumor were ...

Wee1-like protein kinase (WEE1) physiologically serves a key function in maintaining the integrity of the cell genome through mediating the activation of cyclin-dependent kinase (CDK)1 and CDK2. Increased expression of WEE1 has been associated with the poor prognosis of patients with ovarian cancer. The present study aimed at examining the in vitro and in vivo antitumor activity of MK1775, a po...

Background: Ovarian reserve and ovarian response both are of the most important key factors in infertility treatment. Anti mullerian hormone (AMH) is one of lab tests that can predict ovarian reserve. relation between this assay and ovarian response can guide physition to choose the best protocol for the worst reserve. Materials and Methods: In a prospective cohort study, 110 infertile women (2...

•Dermatomyositis in ovarian cancer responds to treatment with neo-adjuvant carboplatin and paclitaxel in conjunction with corticosteroids.•Recurrence of dermatomyositis symptoms is often the first sign of relapsed disease.•Prognosis of ovarian cancer in context of dermatomyositis is poor.

•Primary ovarian neuroblastomas are extremely rare and have poor prognoses.•This report provides results of the same combination therapy in two cases, which indicated its efficacy for ovarian neuroblastoma.