A reversed-phase gradient elution system is described for the simultaneous separation of the type I and type III isomers of 8-, 7-, 6-, 5- and 4-carboxylated porphyrins and isocoproporphyrins. The method, adaptable for isocratic and stepwise separation of individual groups of isomers, is also suitable for preparative isolation of pure porphyrins. The analyses of porphyrin isomers in the urine a...

Measurement of porphyrins and porphyrin precursors has clinical significance beyond the detection or confirmation of lead poisoning. The porphyric diseases of man are characterized by the presence of a specific clinical syndrome and demonstration of abnormal porphyrin excretion or accumulation in the tissues. In addition, porphyrins accumulate in other disorders that are unrelated to lead poiso...

Hepta-, hexa-, and pentacarboxylic porphyrins have been detected in porphyric as well as normal urine samples. From the former they have been isolated and converted into pure methyl esters (1). For a better understanding of the chemistry of these porphyrins, pure uroporphyrin I and uroporphyrin III were separately subjected to decarboxylation under controlled conditions. The decarboxylation pro...

Thirty patients suffering from chronic kidney disease were examined for urinary, fecal and total plasma porphyrins. Twenty patients had nitrogen retention whereas the remaining ten patients displayed normal values. Urinary coproporphyrin excretion and total plasma porphyrin levels were comparatively less pronounced in patients with nitrogen retention. Such changes in porphyrin metabolism could ...

It is well known that porphyrins can be adsorbed on to precipitates of calcium salts, and adsorption can take place under the most varying conditions. Thus, it has been shown that in certain diseases porphyrins are found to be adsorbed on to urinary sediments of calcium phosphates (Garrod, 1892; Dobriner, 1936; Sveinsson, Rimington, and Barnes, 1949) and on to the bone and tooth tissue in mammals.

136 Application of viscometric methods for studying the interaction of various porphyrins with DNA Vigen G. Barkhudaryan & Gayane V. Ananyan To cite this article: Vigen G. Barkhudaryan & Gayane V. Ananyan (2015) 136 Application of viscometric methods for studying the interaction of various porphyrins with DNA, Journal of Biomolecular Structure and Dynamics, 33:sup1, 88-88, DOI: 10.1080/07391102...

The redox properties of metalloporphyrins have been studied extensively, and particular attention has been paid to the changes in oxidation states of the metaL t-3 In general, the most stable metalloporphyrins are those in which the metal is in the + 2 oxidation state. However, most of the transition metalloporphyrins show a variety of oxidation states. Thus Co(ll) porphyrins can, like the corr...

Iron(II) porphyrin nitrosyl complexes are obtained in high yields from the reaction of iron(III) porphyrins with the nitroxyl donors sodium trioxodinitrate and toluensulfohydroxamic acid. The reaction was found to proceed both in organic solvents and in aqueous media from iron(III) (meso-tetraphenyl) porphyrinate ([FeIII(TPP)]+) and iron(III) meso-tetrakis (4-sulfonatophenyl) porphyrinate ([FeI...

Development of long-term implantable luminescent biosensors for subcutaneous oxygen has proved challenging due to difficulties in immobilizing a biocompatible matrix that prevents sensor aggregation yet maintains sufficient concentration for transdermal optical detection. Here, Pd-porphyrins can be used as PEG cross-linkers to generate a polyamide hydrogel with extreme porphyrin density (≈5 × 1...

Porphyrins and fullerenes are spontaneously attracted to each other. This supramolecular recognition element can be exploited to produce ordered arrays of interleaved porphyrins and fullerenes. C(60) x H(2)TpyP x Pb(NO(3))(2) x 1.5TCE (H(2)TpyP = tetra-4-pyridylporphyrin; TCE = 1,1,2,2-tetrachloroethane) crystallizes in the tetragonal P4/n space group and the structure has been solved to high r...