OBJECTIVE To examine the frequency and phenotype of Th17 cells in the peripheral blood of early RA (eRA) patients. METHODS CD4+ T cells were isolated from the peripheral blood of 33 eRA patients, 20 established RA patients and 53 healthy controls (HC), and from the synovial fluid of 20 established RA patients (RASF), by ficoll-hypaque gradient and magnetical negative selection. After polyclon...

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iran is a society with religious infrastructure, in which islam and shiism have had great influence. meanwhile culture and iranian literature, especially poetry has a great position in reflecting religious symbols. ghajarid era is one of the persian literature periods in which religion, especially shiism has great reflection. in this era, by reinforcing religious bases of poems, poets try to tr...

This paper gives the history of verification and validation of discrete-event simulation models as seen through the eyes of its authors and their experiences. The history is divided into three time periods: the early era covering years up to 1970, the awareness era covering the years of the 1970s and 1980s, and the modern era covering the years of 1990 to the present.

AIM To examine whether high-flow nasal oxygen (HFNO) availability influences the use of general anesthesia (GA) in patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic ultrasound (EUS) and associated outcomes. METHODS In this retrospective study, patients were stratified into 3 eras between October 1, 2013 and June 30, 2014 based on HFNO availability for de...

Background Cure rates for chronic hepatitis C have improved dramatically with direct-acting antivirals (DAAs), but treatment barriers remain. We aimed to compare treatment initiation rates and barriers across both interferon-based and DAA-based eras. Methods We conducted a retrospective cohort study of all patients with chronic hepatitis C seen at an academic hepatology clinic from 1999 to 20...

BACKGROUND Identification of parameters for early diagnosis and treatment response would be beneficial for patients with early rheumatoid arthritis (ERA) to prevent ongoing joint damage. miRNAs have features of potential biomarkers, and an altered expression of miRNAs was shown in established rheumatoid arthritis (RA). OBJECTIVE To analyse RA associated miRNAs in the sera of patients with ERA...

OBJECTIVE We wished to determine the prevalence of fever as one of the first symptoms of the enthesitis-related arthritis (ERA) subtype of juvenile idiopathic arthritis. Also, we wished to ascertain if ERA patients with fever at disease onset differed from those without fever. METHODS Consecutive cases of ERA were diagnosed and followed in a retrospective observational study from 1998 to 2013...

OBJECTIVE The purpose of this article is to describe how a neonatal intensive care unit (NICU) was able to reduce substantially the use of postnatal dexamethasone in infants born between 501 and 1250 g while at the same time implementing a group of potentially better practices (PBPs) in an attempt to decrease the incidence and severity of chronic lung disease (CLD). METHODS This study was bot...

BACKGROUND The use of highly active antiretroviral therapy (HAART) may change the incidence of, and the risk and prognostic factors for, invasive pneumococcal disease in patients with human immunodeficiency virus (HIV). METHODS We prospectively studied 142 episodes of pneumococcal bacteremia in 122 HIV-infected adults. Eighty-five episodes occurred in the pre-HAART era (1986-1996) and 57 in t...