Abstract Cranial irradiation (IR) is a cornerstone in the treatment of high-grade pediatric brain tumors. While lifesaving, it associated with severe sequalae 50-90 % survivors, as they often show disabling cognitive dysfunction, declined IQ, impaired processing speed, anxiety and posttraumatic stress symptoms, resulting poorer academic accomplishments social isolation. Memantine (Mem) non-comp...

Trauma to the brain is a leading cause of death and disability. The primary injury initiates a cascade of biochemical reactions in the brain that causes further neuronal damage, a process referred to as secondary brain injury. The mechanisms for secondary brain injury are not fully understood and successful treatments for traumatic brain injury (TBI) still remain elusive. This study was underta...

Achromobacter animicus (A. animicus) is an aerobic, motile, gram-negative, non-fermenting small bacillus that can also grow anaerobically with potassium nitrate. It has been isolated from sputum of humans suffering from respiratory infections. Literature regarding the role of A. animicus in wound infections is limited. We report a first case of a chronic post-traumatic wound infection caused by...

Major trauma is the leading cause of death in young adults. Despite advances in prehospital system and treatment in hospital, mortality rates have not improved significantly over the past decades. Victims of severe injuries who survive the initial hours have great risk for additional life-threatening complicaitons, including uncontrollable infection (sepsis) and multiple organ dysfunction syndr...

For the past 50 years, the medical profession has understood ‘‘brain death’’ to represent the endpoint of a neuropathologic vicious cycle. An initial major brain injury sets off a mutually exacerbating cascade of cerebral edema, increased intracranial pressure, and decreased cerebral blood flow, which advances beyond some point-of-no-return to a state of no cerebral blood flow and total brain i...