BACKGROUND Schistosoma mansoni and malaria infections are often endemic in the same communities in sub-Saharan Africa, and both have pathological effects on the liver and the spleen. Hepatosplenomegaly associated with S. mansoni is exacerbated in children with relatively high exposure to malaria. Treatment with praziquantel reduces the degree of hepatosplenomegaly, but the condition does not co...

To cite: Mikulich O, Chaila E, Crotty JM, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/ bcr-2013-200229 DESCRIPTION Neurological manifestations of schistosomiasis are rare. Early treatment can prevent disability. A 28-year-old Sudanese man, living in Ireland for 5 years, presented with severe lower back pain, flaccid paraplegia, sensory level (T8) and urinar...

OBJECTIVE To investigate the possible effect of artesunate (ART) on schistosome thioredoxin glutathione reductase (TGR) and cytochrome c peroxidase (CcP) in Schistosoma mansoni-infected mice. METHODS A total of 200 laboratory bred male Swiss albino mice were divided into 4 groups (50 mice in each group). Group I: infected untreated group (Control group) received a vehicle of 1% sodium carbony...

PROBLEM Annual mass drug administration (MDA) with safe oral anthelminthic drugs (praziquantel, ivermectin and albendazole) is the strategy for control of onchocerciasis, lymphatic filariasis (LF) and schistosomiasis. District health officers seek to integrate treatment activities in areas of overlapping disease endemicity, but they are faced with having to merge different programmatic guidelin...

BACKGROUND More than 260 million people live with schistosomiasis and regular mass-treatment should be implemented to prevent morbidity. Praziquantel, dosed at 40 milligrams per kilogram bodyweight, is the drug of choice. During the last decades the WHO Tablet Pole-which estimates tablet need by height as representing weight-has been used as a practical and cheap tool in mass treatment. In Sout...

Prior study has suggested that praziquantel could be used in lower doses, one-third than the conventional, when associated to BCG in non reactors patients to PPD (N Nohmi et al. 1993, IV International Symposium on Schistosomiasis, p. 165). In schistosomiasis, a higher degree of protective immunity was obtained when BCG was used in combination with a non-living vaccine of schistosomula (SL James...

A patient with intravitreous cysticercosis was treated with the new anthelminthic drug, praziquantel. A transient toxic effect on the cysticerus was observed, but the drug was unable to kill the parasite.