Acute haemodynamic effects of single dose oral prazosin were studied in eight patients with mitral regurgitation. Heart rate, mean systemic arterial pressure, pulmonary arterial pressure, left ventricular filling pressure, and forward cardiac output were measured in all patients. At peak effect, prazosin reduced mean systemic arterial pressure (95 +/- 4 to 86 +/- 4 mmHg), pulmonary arterial pre...

Short-term vasodilators increase exercise cardiac output without an increase in exercise tolerance when administered to chronic heart failure patients. This study was designed to examine cardiac output, oxygen consumption, and lactate metabolism during exercise in chronic heart failure. Thirteen patients participated in 17 studies during control exercise (C) and during vasodilator exercise afte...

Antibodies were raised against a newly synthesized analog (CP57,609) of the alpha 1-selective antagonist prazosin, and against the alpha 2-selective antagonist, yohimbine, by immunization of rabbits with antigens prepared by covalent linkage of these ligands to albumin. Competitive inhibition of [3H]prazosin binding to anti-CP57,609 antiserum by a variety of unlabeled ligands revealed a spectru...

Early morning reduction in endothelium-dependent, flow-mediated dilation (FMD) may contribute to the high incidence of sudden cardiac death at this time of day. The mechanisms underpinning diurnal variation in FMD are unclear, but potentially relate to a circadian rhythm in sympathetic nerve activity. We hypothesized that blockade of α(1)-mediated sympathetic nerve activity would act to attenua...

Increased skeletal muscle capillarization is associated with improved glucose tolerance and insulin sensitivity. However, a possible causal relationship has not previously been identified. Therefore, we investigated whether increased skeletal muscle capillarization increases insulin sensitivity. Skeletal muscle-specific angiogenesis was induced by adding the α1-adrenergic receptor antagonist pr...

Effectiveness of E-643, a newly developed alpha-blocker, and four alpha-antagonists in blocking pre- and postsynaptic alpha-adrenoceptors were compared in the isolated rat vas deferens. The inhibitory effect of clonidine on the field-stimulated twitch response was antagonized in the presence of the alpha-antagonist. The order of affinity (pA2) for presynaptic alpha-receptors, as assessed from p...

BACKGROUND/OBJECTIVE In the present study, the effect of acute lead exposure in the presence and absence of dopamine or alpha (alpha)-adrenoceptor agents on contractile response of rat isolated thoracic aorta was studied. METHODS Male Wistar rats were used in all experiments. Thoracic aorta was carefully removed, cleaned, and cut into 2-mm thick rings. The rings were mounted for measurement o...

Animal models of neuropsychiatric disorders are current topics in behavioral neuroscience. Application of non-competitive antagonists of NMDA receptors (such as MK-801) was proposed as a model of schizophrenia, as it leads to specific behavioral alterations, which are partly analogous to human psychotic symptoms. This study examined an animal model of schizophrenia induced by a systemic applica...

This study was conducted at the laboratory of histology and anatomy, Faculty Medical Health Techniques/Kufa, post Graduate/ Department biology, Science/University Kufa, The present to investigate effect Prazosin hydrochloride on some organs in male rats (Rattus norvegicus), about 25 mature with average body weight 210-290gram three months age were randomly divided into four groups (5rats / grou...

The SLC22A1 influx transporter is expressed on the basolateral membrane of hepatocytes and is involved in the excretion of numerous cations. Inhibition of SLC22A1 by several antiretrovirals, such as the protease inhibitor darunavir, has not previously been determined. In order to better understand and predict drug-SLC22A1 interactions, a range of antiretrovirals were screened for SLC22A1-associ...