Strain-induced adaption of bone has been well-studied in an axial loading model of the mouse tibia. However, most outcomes of these studies are restricted to changes in bone architecture and do not explore the mechanical implications of those changes. Herein, we studied both the mechanical and morphological adaptions of bone to three strain levels using a targeted tibial loading mouse model. We...

UNLABELLED Using a mechanical loading program to induce bone adaptation, we found that small (<2-fold) changes in the structural properties of the rat ulna increased its fatigue resistance >100-fold. This indicates that a moderate exercise program may be an effective preventative strategy for stress fractures. INTRODUCTION There are currently limited preventative strategies for stress fractur...

OBJECTIVE The present study aims to investigate the influence of presence and shape of cervical lesions on biomechanical behavior of mandibular first premolar, subjected to two types of occlusal loading using three-dimensional (3D) finite element method (FEM). MATERIALS AND METHODS 3D models of the mandibular premolar are created from a micro computed tomography X-ray image: model of sound ma...

The purpose of this paper is to apply stress constraints to structural topology optimization problems with design-dependent loading. A comparison of mass-constrained compliance minimization solutions and stress-constrained mass minimization solutions is also provided. Although design-dependent loading has been the subject of previous research, only compliance minimization has been studied. Stre...

As a sequel to a recent work we consider the generalized stress concentration factor, a purely geometric property of a body that for the various loadings, indicates the ratio between the maximum of the optimal stress and maximum of the loading fields. The optimal stress concentration factor pertains to a stress field that satisfies the principle of virtual work and for which the stress concentr...

In this paper, the present investigation has been conducted keeping in mind some of the problems concerning the crack propagation direction and growth under constant loading in an inclined crack geometry. The present studies mainly focused on the development and modifications in the crack growth criterion to account the biaxial, shear loading and number of stress terms. Existing criteria for th...

The probability of an instant rail break, initiated at a single pre-existing foot crack due to severe wheel impact loading, is predicted using statistical methods and time-domain model for the simulation dynamic vehicle–track interaction. A linear elastic fracture mechanics approach employed calculate stress intensity in continuously welded subjected combined bending temperature loading. Based ...

An investigation into the effect of countersunk depth, plate thickness, countersunk angle and plate width on the stress concentration around countersunk hole is carried out with the help of finite element analysis. The variation of stress concentration with respect to these parameters is studied for three types of loading viz. uniformly distributed load, uniformly varying load and functionally ...

background: lead toxicity is a prevalent health problem in both developed and developing countries. one of the proposed mechanisms for lead-induced organ damage is oxidative stress. oxidative stress is well-associated with the pregnancy disorder, pre-eclampsia. exposure to lead may be one of the sources of the oxidative stress that leads to development of pre-eclampsia in pregnant women. object...