Molecularly targeted agents promise to revolutionize therapeutics by reducing morbidity and mortality in patients with cancer. However, despite an urgent need for more effective anticancer compounds, current preclinical drug evaluations largely fail to satisfy the demand. New preclinical strategies, including the improvement of sophisticated mouse models and co-clinical study designs, are being...

In Electrophysiology catheter ablation is an established treatment for cardiac arrhythmias. Nevertheless, complicated ablation procedures such as Pulmonary vein isolation for atrial fibrillation treatment are difficult to learn. This can be improved by a better integration of the image modalities available today and in the future Electrophysiology lab. In this paper, we present a method to regi...

Simple macroeconomic models based on IS-LM have become unfashionable because of their lack of microfoundations, and are in danger of being effectively forgotten by the profession. Yet while thinking about micro-foundations is a productive enterprise, complex models based on such foundations are not necessarily more accurate than simple, ad-hoc models. Three decades of attempts to base aggregate...