treatment of central precocious puberty (cpp) is the administration of gnrh analogs. metabolic syndrome comprised metabolic disturbances that confer increased risk of (cvd) diabetes mellitus (dm) and cardiovascular disease. this study is a longitudinal prospective study in pediatric endocrinology clinic. 30 non-obese children with idiopathic cpp were involved. total body weight, height, blood p...

Introduction Puberty is a defining developmental stage of every child’s life, both physically and psychosocially. Concerns about the normalcy of pubertal development and menstrual patterns are among the most common questions posed to every physician caring for children. This article reviews the primary physiologic changes in the hypothalamicpituitary-gonadal (HPG) axis and in adrenal androgen a...

Methods Clinical Records of 17 children (16 girls and 1 boy) were retrospectively analyzed over a period of 24 months (Mar 2012 to Mar 2014). All children satisfied the criteria for precocity based on clinical features, radiological assessment and GnRHa stimulation test. All 16 girls had idiopathic precocious puberty and the only boy had hypothalamic hamartoma. The mean age of presentation was ...

The study compared body image and levels of self-esteem and depression between girls with precocious puberty and typical girls, identifying relationships between variables. Data were collected from July until August 2014. Study participants were firstto fourthyear female students in the D region who were diagnosed with precocious puberty in E university hospital and typical students in the same...

Premature activation of the hypothalamic-pituitary-gonadal (HPG) axis manifests as gonadotropin-dependent precocious puberty. The mechanisms behind HPG activation are complex and a clear etiology for early activation is often not elucidated. Though collectively uncommon, the neoplastic and developmental causes of gonadotropin-dependent precocious puberty are very important to consider, as a del...

Endocrine studies in girls with precocious thelarche were compared with those of normal girls of similar ages. Girls with precocious thelarche showed breast development and oestrogenised vaginal smears as the only signs of precocious sexual development. A few of the girls were tall and some had advanced bone ages but these two findings were not consistently present in the same patient. Hormones...

hypothalamic hamartoma (hh) is a rare intracranial lesion that usually presents with classic triad of central precocious puberty, gelastic epilepsy, and developmental delay. herein, a 14-year old boy is presented in whom the diagnosis of hh was made by magnetic resonance imaging. while he did not have any complain of precocious puberty, he surprisingly suffered from delay in puberty. the defini...