Objective(s):Eukaryotic translation initiation factor 4E (eIF4E) is overexpressed in cervical cancer (CC). However, the molecular mechanisms are unclear. This study aimed to investigate the molecular mechanism of eIF4E gene overexpression in CC. Materials andMethods:The human papillomavirus (HPV) type 18 E7 and eIF4E mRNAs were measured following knock down or overexpression of E7 gene by RT-P...

regarding the complexity of social systems and the presence of autonomousintervenes, designing and making the future requires a special strategy, which can harmonize these elements with itself. this can be possible by future depicting, which makes an insight into the desired future, and presents a real perspective of it; and/or it promotes a planned perception of the desired status to impose a...

decision making on budgeting is one of the most important issues for executing managers. budgeting is a major tool for planning and control of projects. in public and non-profit organizations and institutions, estimating the costs and revenues plays an important role in receiving credit and budgeting. in this regard, in the present paper the case of isfahan municipality is considered. one of th...

Knock down efficacy of commercially available insecticides against Anopheles gambiae Nicholas K. Makworo , Vincent O. Ochieng, Dorington Ogoyi, Richard W. Mukabana

The phenomenon of knock is an abnormal combustion occurring in spark-ignition (SI) engines and forms a barrier that prevents increase thermal efficiency while simultaneously reducing CO2 emissions. Since knocking highly stochastic, cyclic analysis in-cylinder pressure necessary. In this study we propose approach for efficient robust detection identification three different internal engines. pro...

background: leishmaniasis represents a major public health concern in tropical and sub-tropical countries. at present, there is no efficacious vaccine against the disease and new control methods are needed. one way to access this important goal is to knock out genes of specific macromolecules to evaluate the effect of deletion on the growth, multiplication, pathogenesis and immunity of the para...

The CRISPR/Cas9 system is widely used for genome editing in livestock production, although off-target effects can occur. It the main method to produce genome-edited goats by somatic cell nuclear transfer (SCNT) of CRISPR/Cas9-mediated primary goat fetal fibroblast cells (GFFs). Improving double-strand break (DSB) efficiency Cas9 would improve homologous repair (HR) efficiency. low HR remains a ...

Spark timing of an Internal Combustion (IC) engine is often limited by engine knock in the advanced direction. The ability to operate the engine at its advanced (borderline knock) spark limit is the key for improving output power and fuel economy. Due to combustion cycle-to-cycle variations, IC engine combustion behaves similar to a random process and so does the engine performance criteria, su...

BACKGROUND Protein-tyrosine kinases (PTKs) regulate virtually all biological processes. PTKs phosphorylate substrates in a sequence-specific manner and relatively short peptide sequences determine selectivity. Here, we developed new technology to determine PTK activity profiles using peptide arrays. The zebrafish is an excellent model system to investigate signaling in the whole organism, given...