Prenylated 1,3-dihydroxyxanthone has been successfully synthesized using Prenyl bromide and KOH. Characterization of the compound Infra Red (IR) Nuclear Magnetic Resonance (1H-NMR) showed that monosubstituted c-prenylation was occurred at carbon number 2 to form 1,3-dihydroxy-2-prenylxanthone. The synthesis result a yellow-brown paste with yield 43.09%. This prenylated had moderate antibacteria...

Twelve phosphonopropionates derived from 2-hydroxy-3-imidazo[1,2- a ]pyridin-3- yl -2-phosphonopropionic acid (3-IPEHPC) were synthesized and evaluated for their activity as inhibitors of protein geranylgeranylation. The nature the substituent in C6 position imidazo[1,2- ]pyridine ring was responsible compound's against Rab geranylgeranyl transferase (RGGT). most active disrupted Rab11A prenyla...

Background The ApoE4 allele is the strongest known genetic risk factor for late onset Alzheimer’s disease. Despite this knowledge, therapeutic strategies seeking to modulate brain ApoE homeostasis remain largely unexplored. Several lines of evidence demonstrate that astrocytes function as primary producers within brain. In study, we examine how targeted disruption astrocyte lipid metabolism and...