A new method for synthesis of amides and hydroxamic acids from nitroarenes and aldehydes is described. The MnO2 catalyzed thermal deoxygenation of nitrobenzene resulted in formation of a reactive nitroso intermediate which on reaction with aldehydes provided amides and hydroxamic acids. The thermal neat reaction in the presence of 0.01 mmol KOH predominantly led to formation of hydroxamic acid ...

A nickel-catalyzed α-arylation of esters and amides with phenol derivatives has been accomplished. In the presence of our unique nickel catalyst, prepared in situ from Ni(cod)2, 3,4-bis(dicyclohexylphosphino)thiophene (dcypt), and K3PO4, various esters and amides undergo α-arylation with O-arylpivalates or O-arylcarbamates to afford the corresponding coupling products. The thus obtained α-aryl ...

We report the first one-pot reductive homocoupling reaction of secondary amides and cross-coupling reaction of secondary amides with ketones to give secondary vicinal diamines and amino alcohols. This method relies on the direct generation of α-amino carbon radicals from secondary amides by activation with trifluoromethanesulfonic anhydride, partial reduction with triethylsilane and samarium di...

Kinetically unstable isocyanides as vinyl, allenyl and propargyl react in Passerini Ugi reactions faster than they decompose lead to functionalized α-acyloxy amides α-amino amides, respectively, which can subsequently be used involving the unsaturated substituent.

An undergraduate laboratory was developed as part of the Drugs for Neglected Diseases initiative’s Open Synthesis Network. This activity aimed to develop new compounds efficacious against visceral leishmaniasis. Students successfully synthesized, purified, and characterized ten different benzoxazole amides that were sent biological testing several protozoan parasites. Although all had poor L. d...

A series of acylated derivatives of 3,4-methylenedioxy-methamphetamine (3,4-MDMA) are prepared and evaluated in gas chromatography-mass spectrometry (GC-MS) studies. The perfluoroalkyl amides of 3,4-MDMA show the lowest GC retention, while the aromatic amides such as the benzamide show the greatest retention on the dimethylpolysiloxane stationary phase (Rtx-1). The mass spectral properties of t...

Ever since their first synthesis in 1974 monomeric tin(II) and lead(II) amides have attracted con­ siderable interest as a consequence of their carbenoid electronic structure [1 6]. Although the sub­ stituents at the nitrogen atoms have been varied to some extent, N-dialkylboryl groups have received only scant attention. One attempt to use a N-dimethylboryl group has afforded a dimer after elim...

Two new feruloyl amides, N-cis-hibiscusamide (5) and (7'S)-N-cis-feruloylnormetanephrine (9), and eight known feruloyl amides were isolated from Portulaca oleracea L. and the geometric conversion of the ten isolated feruloyl amides by UV light was verified. The structures of the feruloyl amides were determined based on spectroscopic data and comparison with literature data. The NMR data reveale...

The Cover Feature illustrates the photochemical conversion of carboxylic acids to Weinreb and morpholine amides. Sunlight or LED 370 nm irradiation mediates direct coupling N,O-dimethylhydroxylamine in presence 4-dimethylaminopyridine bromotrichloromethane, providing corresponding amides satisfactory high yields. More information can be found Research Article by C. G. Kokotos, Kokotos et al.