PURPOSE To evaluate the vasoactive response of isolated perfused arteries of the pig to K+ and adrenergic agonists and to compare the effects of intraluminal (IL) and extraluminal (EL) drug delivery. METHODS A new microperfusion system was developed, in which short lengths of porcine retinal arteries (outer diameter 90.4 +/- 2.7 microns) were cannulated at both ends and perfused at a controll...

Burger NZ, Kuzina OY, Osol G, Gokina NI. Estrogen replacement enhances EDHF-mediated vasodilation of mesenteric and uterine resistance arteries: role of endothelial cell Ca . Am J Physiol Endocrinol Metab 296: E503–E512, 2009. First published January 6, 2009; doi:10.1152/ajpendo.90517.2008.—Endothelium-derived hyperpolarizing factor (EDHF) plays an important role in the regulation of vascular m...

BACKGROUND AND PURPOSE Parenchymal arterioles (PAs) are high-resistance vessels in the brain that connect pial vessels to the microcirculation. We previously showed that PAs have increased vasoconstriction after ischemia and reperfusion that could increase perfusion deficit. Here, we investigated underlying mechanisms by which early postischemic reperfusion causes increased vasoconstriction of ...

Regulation of cochlear blood flow is critical for hearing due to its exquisite sensitivity to ischemia and oxidative stress. Many forms of hearing loss such as sensorineural hearing loss and presbyacusis may involve or be aggravated by blood flow disorders. Animal experiments and clinical outcomes further suggest that there is a gender preference in hearing loss, with males being more susceptib...

We hypothesized that resistance arteries from diabetic patients with controlled hypertension have less remodeling than vessels from untreated hypertensive subjects. Eight normotensive subjects (aged 44+/-3 years, 3 men; values are mean+/-SEM), 19 untreated hypertensive subjects (46+/-2 years, 9 men), and 23 hypertensive subjects with type 2 diabetes mellitus under antihypertensive treatment (58...

To The ediTor: It is with great interest that we read the article by Hirsch et al, “The use of vertebral augmentation and external beam radiation therapy in the multimodal management of malignant vertebral compression fractures,” published in the 2011 September/October issue of Pain Physician (1). This is a thoughtful and well-designed retrospective article which suggested palliation to patient...

An intensive investigation has been carried out to study the surface profiles obtained as a result of the large deformations of pressurized membranes. The study shows that the inflated membrane shapes may have the requisite surface accuracy for use in finure large space apertures. Both analytical and experimental work have been carried out. On the analytical side, the classical work of Hen&y on...

in this research, the effect of friction between the liquid metal and the sand mould wall and the effect of passage of liquid through a vertical bend and through a ceramic filter on the fluid flow and the melt velocity has been studied by measuring the velocity of the melt and direct observation of the liquid flow through the different parts of a naturally-pressurized running system. the fricti...

INTRODUCTION: Surgical site infection can occur after internal fixation of both open and closed fractures following internal fixation. Common methods of infection management include operative debridement and wound irrigation with a bulb syringe, or pressurized pulsatile lavage. The Versajet hydrosurgery tool appears to be an effective tool for debridement. Arecent study found that the Versajet ...