PURPOSE In order to assess whether focal epileptic seizures can be detected and distinguished from exercise we evaluated four different heart rate variability (HRV) methods with short term moving window analysis of 30, 50 or 100 R-R intervals or seconds per analyzed window. METHODS The four methods consisted of: (1) reciprocal high frequency power based on Fast Fourier Transformation, (2) Car...

objective the lennox-gastaut syndrome (lgs: the triad of intractable seizures of various types, a slow spike-wave pattern in eeg and mental retardation) is one of the most difficult epilepsy syndromes to treat. the aim of this study was to evaluate the efficacy and safety of zonisamide (zns) as add-on therapy in seizures of children with lgs. materials & methods in a quasi- experimental study, ...

PURPOSE To evaluate the efficacy, safety, and tolerability of lacosamide in adults with LGS in the clinical setting. METHOD The present report is a retrospective, open-label treatment study carried out from June 2013 to December 2014 at the National Institute of Colombia. Lacosamide was introduced as add-on therapy. All caregivers were instructed to initiate lacosamide at low doses (25-50 mg)...

A 47-year-old man presented with tonic-clonic seizures characterized by convulsions. He repeatedly exhibited despite treatment four anti-seizure medications. During the titration process of perampanel (PER), paradoxically increased in intensity and frequency, resulting trauma. Video electroencephalogram monitoring revealed interictal rapid rhythms generalized spikes documented atonic seizures. ...

Fahr’s disease is a rare sporadic or inherited neurodegenerative disorder characterized by symmetrical bilateral calcifications in the basal ganglia and some other brain structures – dentate nucleus, thalamus, cerebral cortex, subcortical white matter, and hippocampus. We report a patient with Fahr’s disease who was monitored for 11 years. The case is of interest for clinical practice because o...

We report the case of 36-year-old woman who had suffered from focal-unilateral right febrile grand mal since she was 9 months old as a result of neonatal asphyxia. Over the years, a modification of the clinical picture occurred and eventually the patient suffered from paranoid delusions that impaired her ability to work. After many years free from seizures, she experienced one day a generalized...