Patients with an aldosterone-producing adenoma (APA) characteristically fail to show an increase in plasma aldosterone (PA) concentration with maneuvers that increase angiotensin II (Ang II), yet they retain a brisk response of PA to adrenocorticotrophic hormone. Therefore, adrenal Ang II receptor binding was characterized in a patient with APA who had a blocked PA response to Ang II infusion b...

P rimary hyperaldosteronism in pregnancy is a rarely reported clinical entity that may result in life-threatening complications both for mother and the fetus and is most often caused by an aldosterone producing aden oma (APA). The physiologic rise in aldosterone during pregnancy overlaps the levels seen in primary aldosteronism, making diagnosis difficult. Suppressed renin in the setting of hyp...

Primary aldosteronism has been considered a rare disease in the past years, affecting 1% of the hypertensive population. Subsequently, growing evidence of its higher prevalence is present in literature, although the estimates of disease range from 5 up to 20%, as in type 2 diabetes and resistant hypertension. The main reasons for these variations are associated with the selection of patients an...

Glucocorticoid-remediable aldosteronism is a hereditary form of primary hyperaldosteronism and the most common monogenic cause of hypertension. We present the case of a 24-year-old man with a family history of Conn's syndrome. Yet, in the index patient, classical characteristics of mineralocorticoid excess could be reversed by exogenous glucocorticoids.

90 Maedica A Journal of Clinical Medicine, Volume 7 No.1 2012 Update in Endocrinology – Primary Hyperaldosteronism – From Secondary Hypertension Towards Metabolic Syndrome and Beyond Raluca-Alexandra TRIFANESCU, MD, PhDa,b; Catalina POIANA, MD, PhDa,b aEndocrinology Department, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania b“C.I.Parhon” National Institute of Endocrinolo...

OBJECTIVES To study the long-term outcome of patients with primary hyperaldosteronism who underwent laparoscopic adrenalectomy and to determine the preoperative predictive factors of persistent hypertension. METHODS Between 1996 and 2002, 47 patients with primary hyperaldosteronism underwent transperitoneal laparoscopic adrenalectomy at our institution. Their clinical and biochemical paramete...

We report the case of a 48-year old man with uncontrolled hypertension and persistent hypokalaemia from an aldosterone producing adrenal adenoma treated by laparoscopic adrenalectomy. Clinicians' identification of primary hyperaldosteronism is critical as the correct treatment results in improved blood pressure control and reduced risk of complications.