It is well-known that pulmonary hypertension can complicate infection by the human immunodeficiency virus (HIV). The incidence of primary pulmonary hypertension in HIV positive patients is unknown, but could be higher than 0.5%, in comparison with an 0.02% incidence in the general population. Since 1987, 131 cases of pulmonary hypertension associated with HIV infection have been published.1 A t...

Heterobimetallic NiZn complexes featuring metal centers in distinct coordination environments have been synthesized using diimine-dioxime ligands as binucleating scaffolds. A tetramethylfuran-containing ligand derivative enables a stable one-electron-reduced S = 1/2 species to be accessed using Cp2Co as a chemical reductant. The resulting pseudo-square planar complex exhibits spectroscopic and ...

This is an opportune time to reappraise primary pulmonary hypertension. The disease is still incurable but recent laboratory studies are beginning to provide clues to its pathogenesis, and we now know that survival is improved by sustained intravenous prostacyclin treatment and by chronic anticoagulation. In 1991, before these treatments were generally available, the median survival was given a...

Seven women with primary pulmonary hypertension underwent hemodynamic evaluation, at rest and during exercise, before and after the oral administration of captopril. Dose-response curves were generated for the 25-, 50- and 100-mg doses. Captopril significantly reduced systemic blood pressure and systemic vascular resistance; these effects persisted at submaximal levels of exercise. Captopril di...

Thromboembolism is a rare complication of primary nephortic syndrome. Both venous and arterial thrombosis might occur in steroid responsive and steroid resistant nephrotic syndrome. This is the report of an infant with nephrotic syndrome and renovascular hypertension, complicated with asymptomatic intracardiac thrombus and managed appropriately with medical treatment.

An 8 year old girl with primary pulmonary hypertension and signs of heart failure was given 17.5 mg of verapamil injected into the pulmonary artery over 25 minutes to test for the reversibility of pulmonary arteriolar obstruction. Pulmonary artery pressure fell from 70/50 to 35/25 mm Hg. Treatment with 40 mg verapamil by mouth four times daily was started, and she was discharged. She gradually ...

Pulmonary Hypertension To the Editor: We read with interest the excellent article on primary pulmonary hypertension (PPH) by Archer and Rich in the November 28, 2000, issue of Circulation.1 They did not mention, however, the association between hypothyroidism and PPH. Curnock et al2 have carried out a retrospective review of 41 patients with PPH. Of the 40 patients studied, 9 (22.5%) had eviden...

Background Previously reported cases of patients with pulmonary hypertension (PH) and human immunodeficiency virus (HIV) infection are poorly documented regarding baseline hemodynamics and potential for pulmonary vasodilatation. The purpose of this report was to compare HIV-infected patients who had PH with non-HIV-infected patients who had primary pulmonary hypertension (PPH) in terms of (1) c...

When Paul Wood first described primary pulmonary hypertensionl 2 he believed it to have a vasoconstrictive origin and showed that the pulmonary vascular resistance could be selectively lowered in some but not all of these patients by infusion of acetyl choline into the pulmonary artery3 in contrast to patients with the Eisenmenger syndrome, who were invariably unresponsive.34 The pathogenesis h...