PURPOSE To determine if open-angle glaucoma (OAG)-associated single nucleotide polymorphisms (SNPs) are associated with incident glaucoma and if such genetic information is useful in OAG risk prediction. DESIGN Case-control from within a population-based longitudinal study. METHODS study population: Individuals aged over 49 years of age living in the Blue Mountains region west of Sydney and...

Refractive errors and primary open-angle glaucoma are common eye conditions in the United States. The identification and quantification of risk factors for primary open-angle glaucoma is critical to understanding and managing the disease process from both individual and public health perspectives. This narrative review was conducted to present the epidemiology of primary open-angle glaucoma and...

OBJECTIVE The aim of this study was to determine the prevalence of open angle glaucoma in first-degree relatives accompanying POAG patients during routine examination in a reference hospital. METHOD First-degree relatives of primary open angle glaucoma patients who accompanied their relatives to the glaucoma service of a reference hospital were screened for glaucoma. RESULTS One-hundred and...

The CYP1A1 gene is related to the generation of secondary metabolites that are capable of inducing DNA damage. The CYP1A1m1 polymorphism has been examined in many studies, and is located in a region near loci that have been linked to glaucoma, including the locus GLC1I. As a result, this polymorphism has been related to several diseases that are influenced by exposure to xenobiotic as well as p...

OBJECTIVE To evaluate the characteristics of the design, analysis, and reporting of crossover trials for inclusion in a meta-analysis of treatment for primary open-angle glaucoma and to provide empirical evidence to inform the development of tools to assess the validity of the results from crossover trials and reporting guidelines. METHODS We searched MEDLINE, EMBASE, and Cochrane's CENTRAL r...

Glaucoma is a major cause of blindness worldwide. A single nucleotide polymorphism of the MTHFR gene (C677T) has been associated with susceptibility to this disease, although this is controversial in the last decade. In this study, the possible association between the MTHFR C677T polymorphism and the risk of developing primary open angle (POAG) and pseudoexfoliation glaucoma (PEXG) was investig...

Objective(s): Evaluate the effect of topical antiglaucoma drugs on tear film and determine the time taken to develop symptoms and or signs of dry eye in diagnosed open angle glaucoma patients by Schirmer's test I, Schirmer's test II, Tear film break up time. Method(s): This prospective study was carried out in 60 patients attending Ophthalmology outdoor with newly diagnosed patients of primary ...

PURPOSE The distribution of sensitivity across the visual field, as determined by automated threshold static perimetry, can be summarized in terms of visual field indices. Such indices can be weighted for the variation in threshold at each eccentricity. The aims of this study were to determine the influence of the weighting factor, the relationship between the unweighted indices derived from Pr...

Using the now well established technique ALT is a safe and effective means of lowering IOP in eyes with POAG, pigmentary glaucoma, and exfoliative glaucoma though the effect diminishes with time. Pressure reduction with ALT is seldom greater than 30% and eyes with an IOP of more than 28 mm Hg are unlikely to be controlled for any length of time without additional treatment. ALT is probably most...

OBJECTIVE To map new genetic loci for adult-onset primary open-angle glaucoma (POAG) by using families previously unlinked to GLC1A-GLC1F. METHODS Initial genome scan and subsequent saturation mapping confirmed linkage to a locus on chromosome 2p15-p16. Forty-nine DNA samples from a single family with POAG with 113 individuals were used in this study. The 10 affected members of this family ha...