PURPOSE There is now increasing evidence that pterygium and pinguecula are tumorlike tissues and that cell growth and DNA replication are closely linked to cholesterol metabolism. In this study, the expression of two main genes correlated to cholesterol metabolism--namely, the low-density lipoprotein receptor (LDL-R) gene and the hydroxy-methylglutaryl-coenzyme A-reductase (HMG-CoA-R) gene--wer...

Aim: To compare the recurrence rate of pterygium after excision with free conjunctival autograft versus amniotic membrane graft. Methods: The present study was a comparative, randomised prospective study. One hundred patients who presented with primary pterygium during the study period were randomly assigned to one of the two groupsone group (comprising of 50 patients) underwent pterygium excis...

PURPOSE Pterygium is an ocular surface disease of unknown etiology associated with epithelial and fibrovascular outgrowth from the conjunctiva onto the cornea. S100 proteins are calcium-activated signaling proteins that interact with other proteins to modulate biological functions such as cell migration, proliferation, and differentiation. The aim of this study was to investigate the presence o...

PURPOSE To examine the expression patterns of extracellular matrix degrading enzymes in cultured primary pterygium body fibroblasts activated by cytokines and growth factors potentially derived from ocular surface epithelial cells and tears. METHODS EGF, TGF-alpha, PDGF-BB, IL-1beta, bFGF, TGF-beta1, TNF-alpha, or IL-6 were added at 10 ng/ml to early passaged primary pterygium body fibroblast...

PURPOSE Because the influence of papillomavirus (HPV) in pterygium pathogenesis is controversial, the aim of this study was to identify whether it is present in the pterygia lesions in our region. METHODS Thirty-six patients with unilateral primary pterygia were submitted to excision of pterygia and a sample of normal conjunctiva. Tissues were submitted to polymerase chain reaction (PCR) eval...

.. Objective: To study the results of primary pterygium excision through bare sclera technique with and without intraoperative Mitomycin C use. Study design: This was an experimental study with randomised controlled trial. Setting and Duration: This study was conducted at Eye A unit, Khyber Teaching Hospital, Peshawar from May,2007 to April,2009. Methodology: One hundred patients with primary p...

The standard treatment for pterygium was surgical excision with bare sclera technique which was associated with a high recurrence rate. Therefore adjunct treatment options are used to reduce this recurrence, such as the use of beta radiation, conjunctiva auto graft, amniotic membrane grafting and mitomycin C (1,2). Pterygium recurrence is one of the challenging problem facing ophthalmologists d...

Purpose. It has been confirmed that inflammatory cytokines are involved in the progression of pterygium. Histamine can enhance proliferation and migration of many cells. Therefore, we intend to investigate the proliferative and migratory effects of histamine on primary culture of human pterygium fibroblasts (HPFs). Methods. Pterygium and conjunctiva samples were obtained from surgery, and tolui...