Purpose The purpose of this study was to optimize a peptide (nABP284) that binds programmed cell death protein 1 (PD-1) by computer-based protocol in order increase its affinity. Then, aimed determine the inhibitory effects on cancer immune escape coculturing improving cytokine-induced killer (ICIK) cells with cells. Materials and Methods nABP284 PD-1 identified phage display technology our pre...

Inhibitory properties of PD-1 receptor engagement on activated T cells are well established in physiologic and pathological contexts. In cancer, the use of checkpoint blockade, such as anti-PD-1 antibodies, becomes progressively a reference treatment of a growing number of tumors. Nonetheless, it is also established that PD-1 expression on antigen-specific T cells reflects the functional avidit...