Four recently introduced new oral anticoagulants (dabigatran, rivaroxaban, apixaban and edoxaban) have been shown to be at least as efficacious and safe as warfarin for stroke prevention in patients with atrial fibrillation in their respective trials. The first three have been approved, while edoxaban is awaiting regulatory approval. Several guidelines have endorsed the approved new oral antico...

Twin-studies suggest that a significant portion of individual differences in the propensity to take risks resides in people's genetic make-up and there is evidence that variability in dopaminergic systems relates to individual differences in risky choice. We examined the link between risk taking in a risk taking task (the Balloon Analogue Risk Task, BART) and a variable number tandem repeat (VN...

Young drivers are over-represented in road injury statistics, partly because they engage in more risky driving than older people. Although it is assumed that younger people have greater risk-propensity, defined as a positive attitude to risk, relevant theory is imprecise and relevant research is clouded by inappropriate measures. 89 participants aged 16-25 and 110 participants aged over 35 were...

in the process of investment decision making, next to financial indicators many other aspects of investment projects are increasingly often considered. this leads to the multi-criteria evaluation of a project. the advantage of multi-criteria methods is the ability to take into account all (not only financial) aspects of the attractiveness of an investment project. the selection of criteria of p...

Individuals differ not only in their background characteristics, but also in how they respond to a particular treatment, intervention, or stimulation. In particular, treatment effects may vary systematically by the propensity for treatment. In this paper, we discuss a practical approach to studying heterogeneous treatment effects as a function of the treatment propensity, under the same assumpt...

Although a number of quantitative risk management measures and methods have been developed, the risk decision-making behaviour of construction project managers still needs to be further considered. Taking the characteristics of construction projects into consideration, this research put forward an integrated framework from the perspective of construction project managers and proposes 11 general...