The discovery of insulin has entirely changed the prognosis of diabetes in childhood. Whereas in pre-insulin days the outlook was almost hopeless, the patient seldom lived longer than two years, the prognosis now appears to be very favourable. Growth is perfectly normal as are physical andc mental activity, and there does not appear to be any increased susceptibility to infections although the ...

The rapidity of environmental degradation and the recent popularity of the concept of sustainability have made clear how successful traditional societies have been in coexisting with nature. Architects, in responding to this rising awareness, are searching for models of the reinterpreta­ tion of tradition, seeking examples and guidelines. Three practitioners who anticipated the need for a reexa...

We introduce a novel method called Prophetic Granger Causality (PGC) for inferring gene regulatory networks (GRNs) from protein-level time series data. The method uses an L1-penalized regression adaptation of Granger Causality to model protein levels as a function of time, stimuli, and other perturbations. When combined with a data-independent network prior, the framework outperformed all other...

While the concepts involved in Self-Organized Criticality have stimulated thousands of theoretical models, only recently have these models addressed problems of biological and clinical importance. Here we outline how SOC can be used to engineer hybrid viral proteins whose properties, extrapolated from those of known strains, may be sufficiently effective to cure cancer. Self-Organized Criticali...

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I think that contemporary society is like a great, complex network of attitudes, values, and worldviews, in which everything exists within different cultures and environments. This network keeps changing at every moment, with different parties interacting with each other, so that each experience that we come across can become an exciting source and medium for creation. As for music composition,...

Paradoxically, in the globalized world, contemporary architecture is represented as an illustration of the contemporary rupture between the rigor of structural geometry and the turgid corpulence of imagination. Moreover in times of cultural globalization local specificities dissolve. Nevertheless, there are trends, cultural traits, and influences of critical or intellectual tradition that persist.