PURPOSE Dramatic improvement of hemangioma to propranolol has been recently reported; however, details on dose and duration of treatment, potential risks, and monitoring have not been determined. The objective of this study is to describe and analyze the use of propranolol as a first-line treatment or as a single therapy in management of complicated hemangioma. METHODS A retrospective chart r...

background: prolongation of qt interval is one of the most important abnormalities in cardiovascular system of cirrhotic patients. the aim of this survey was determination of propranolol effect on frequency adjusted qt interval (qtc). materials and methods: thirty six cirrhotic patients (m/f=20/16, mean age:56 â± 3.8 years) and 40 healthy age and sex matched controls (m/f=25/15, mean age: 58 â±...

how to cite this article: tonekaboni sh, ghazavi a, fayyazi a, khajeh a, taghdiri mm, abdollah gorji f, azargashb e. prophylaxis of childhood migraine: topiramate versus propranolol. iran j child neurol. 2013 winter; 7 (1):9-14.   objective headache is a common disabling neurological disorder and migraine comprises more than half the causes of recurrent headaches in children. despite extended p...

BACKGROUND A recent large-scale, chemical screening study raised the hypothesis that propranolol may increase the risk of myopathy. We tested this hypothesis in a large population to assess whether (1) propranolol use is associated with an increased risk of myopathy and (2) the concurrent use of propranolol with a statin may further increase risk of myopathy. METHODS New users of propranolol ...

1. a,-Adrenoceptor-mediated vasoconstriction was studied before and during propranolol therapy in eight normal renin essential hypertensive patients; four were known ‘responders’ and four, age-matched ‘non-responders’ to previous p-receptor blocker monotherapy. Plasma renin activity, plasma adrenaline and noradrenaline concentrations as well as forearm blood flow were measured before and during...

The efficacy and safety of oral nadolol in supraventricular tachycardia were evaluated prospectively in 27 children (median age 5.5 years). Fifteen patients had an unsuccessful trial of digoxin therapy. Intravenous nadolol was given to seven patients during electrophysiologic study; five of these had an excellent response and two had a partial response (25% decrease in tachycardia rate). Six of...

The ability of propranolol to inhibit the development of polyploidy in aortic vascular smooth muscle cells associated with hypertension was studied in deoxycorticosterone (DOC)-salt treated rats. Six-week treatment with DOC-salt resulted in significant increases in systolic blood pressure, heart weight, and aortic weight in treated animals compared to increases in uninephrectomized controls. Ad...

The aims of this study were to develop a transdermal patch for selective controlled delivery of the active S-enantiomer from racemic propranolol, and to evaluate its performance in vivo using Wistar rats. A molecularly imprinted polymer (MIP) thin-layer composited cellulose membrane with selectivity for S-propranolol was employed as the enantioselective-controlled release system. The effect of ...

Purpose: To evaluate the effects of the methanol extract of Acanthus montanus on guinea pig trachealis muscle. Methods: Guinea pig tracheae were set up in 10 ml organ baths. The effect of the methanol extract of Acanthus montanus (0.5 8 mg/ml) on the spontaneous tone of the trachea and carbacholprecontracted trachea in the absence and presence of propranolol, glibenclamide and procaine was stud...