To investigate the in vivo whole blood metabolic clearance rates and sites of metabolism of prostaglandins A1 and E1 in man, constant infusions of the tritiated compounds were administered to normal subjects and to patients undergoing cardiac catheterization. The whole blood metabolic clearance rate of [3H]prostaglandin A1 in eight men was 5,003 +/- 864 liters/day (SD) or 2,546 +/- 513 liters/d...

We perform shell model calculations in odd-odd nuclei using a quadrupolequadrupole interaction with single-particle splittings chosen so as to obtain the SU(3) results. Elliott had shown that such an interaction gives rotational bands for which the energies go as I(I + 1). This certainly is true for eveneven and for odd-even or even-odd nuclei with K 6= 1/2. We have looked at odd-odd nuclei e.g...

Prostaglandin E1 (PGE1) was compared to placebo in a 100-patient (50 PGE1, 50 placebo) randomized, double-blind, clinical trial to determine whether PGE1 therapy enhances survival of patients with adult respiratory distress syndrome (ARDS) when infused through a central line at 30 ng/kg/min continuously for seven days. At 30 days postinfusion, 30 PGE1 and 24 placebo patients had died. Total dea...

Misoprostol, a prostaglandin E1 analogue, is first used to prevent peptic ulcers. The FDA-approved indication in the product labelling for prevention and treatment of intestinal ulcer disease caused by use nonsteroidal anti-inflammatory medications. main advantages misoprostol include it's reasonably priced, compared other prostaglandins, it has modest effects on smooth muscle heart bronchial t...

We present a case of one-day-old newborn, without prenatal diagnosis, referred to our cardiologic intensive care unit in critical condition presenting sub-cyanosis and peripheral oxygen saturation 80%. Echocardiography diagnosis was tricuspid valve dysplasia with severe regurgitation, functional pulmonary atresia intact ventricular septum reversal flow the large patent ductus arteriosus (PDA). ...