We are reporting a case of systemic lupus erythematosus (SLE) with left upper limb and lower limb deep vein thrombosis (DVT) due to protein S deficiency which was aggravated by anticoagulants. Oral anticoagulant-induced skin necrosis also developed in this patient. This patient was negative for anti-phospholipid antibodies (APLA). Such a case is rarity where SLE patient without APLA has protein...

Purpose: To report a case of branch retinal artery occlusion (BRAO) in a pregnant patient of Chinese descent found to have Protein S deficiency. Case report: A 35 year-old apparently healthy, pregnant female of Chinese origin reported in the eye clinic of our hospital with a complaint of sudden appearance of a “shadow” in the periphery of her left eye for the last three days. On examination, sh...

In this issue of Blood, Holzhauer et al have determined a novel method of identifying patients with protein C, protein S, and antithrombin deficiency who are at increased risk of developing venous thromboembolism (VTE; see figure). Children with VTE and their relatives were screened for inherited thrombophilia including proteins C and S and antithrombin deficiency; and Factor (F)V G1691A and FI...

thrombophilia is a pathological state of increased blood coagulability. it causes problems during pregnancy including preeclampsia, stillbirth, repeated abortions, and detached pair. out of the most prevalent factors causing inherited thrombophilia, protein s (prs), protein c (prc), and antithrombin iii (atiii) deficiency, and factor v leiden (fvl) mutation could be mentioned. this study aimed ...

Protein S (PS) is an antithrombotic plasma protein that plays essential roles in limiting thrombus formation in the anticoagulant system. Protein S deficiency is related with recurrent thrombosis. Here, the authors report a case of a term neonate with severe PS deficiency in year 2015, Imam Hospital, Tehran, Iran, that had seizures and intraventricular hemorrhage (IVH) since the age of 3 days. ...

BACKGROUND Recurrent pregnancy loss (RPL) is a common health problem. The polymorphisms G20210A of prothrombin gene (FII G 20210A), and G 1691A of factor V gene (Factor V Leiden, FVL) are the most extensively studied thrombophilic mutations in association to recurrent miscarriage. OBJECTIVES To determine the frequency of FII G20210A and FVL polymorphisms as well as protein C and protein S def...

Tissue factor (TF) plays an important role in hemostasis, inflammation, angiogenesis, and the pathophysiology of atherosclerosis and cancer. In this article we uncover a mechanism in which protein S, which is well known as the cofactor of activated protein C, specifically inhibits TF activity by promoting the interaction between full-length TF pathway inhibitor (TFPI) and factor Xa (FXa). The s...

OBJECTIVE A single kindred in North America with venous thrombosis was described as having defective fibrinolysis because of increased levels of plasminogen activator inhibitor-1 (PAI-1). Our study describes the discovery of protein S deficiency in this kindred and its association with venous thromboembolism. DESIGN A family study. SETTING Community. PARTICIPANTS Twenty-eight adults (ages...