نتایج جستجو برای: protein tb
تعداد نتایج: 1258604 فیلتر نتایج به سال:
objective: antigen 85 complex of mycobacterium tuberculosis includes three immunogenic proteins which are important tb vaccine candidates. the use of these protein as a component of subunit vaccines, as a part of dna vaccines or recombinant bcg boosters, enhances their recombinant production. recombinant production of these mycobacterial proteins located in the cell wall somehow differs from th...
Tuberculosis (TB) is the deadliest infectious disease worldwide. One obstacle hindering the elimination of TB is our lack of understanding of host-pathogen interactions. Exosomes, naturally loaded with microbial molecules, are circulating markers of TB. Changes in the host protein composition of exosomes from Mycobacterium tuberculosis (Mtb)-infected cells have not been described, can contribut...
introduction: tuberculosis (tb) caused by mycobacterium tuberculosis remains a major worldwide health problem. the only tb vaccine currently available is anattenuated strain of mycobacterium bovis termed bacillus calmette -guerin (bcg).the efficacy of bcg remains controversial. mycobacterium secretory proteins are generally considered important antigens for protection against tb. a major protei...
We studied the immune response of salivary secretory Objective immunoglobulin A (sIg-A) from a pediatric tuberculosis (TB) group (scoring > and =6) and non-TB group (scoring <6) against recombinant Ag38 (Ag38-rec) from Indonesian strain. Mycobacterium tuberculosis : Seventy-eight children were divided into three Materials and Methods groups; those with TB (n=26), those with suspected TB (n=26),...
SETTING Malnutrition and intestinal parasites cause immunosuppression. This may cause false-negative tuberculin skin tests (TST) and failure to identify tuberculosis (TB) infection. OBJECTIVE To assess factors associated with TST positivity and anergy in disadvantaged communities in Peru. DESIGN A study of 212 randomly selected adults: 102 in a rural Amazonian village and 110 shanty town re...
IFN-γ is a critical mediator of host defense against Mycobacterium tuberculosis (Mtb) infection. Antigen-specific CD4+ T cells have long been regarded as the main producer of IFN-γ in tuberculosis (TB), and CD4+ T cell immunity is the main target of current TB vaccine candidates. However, given the recent failures of such a TB vaccine candidate in clinical trials, strategies to harness CD4-inde...
The recent development and spread of extensively drug-resistant and totally drug-resistant resistant (TDR) strains of Mycobacterium tuberculosis highlight the need for new antitubercular drugs. Protein synthesis inhibitors have played an important role in the treatment of tuberculosis (TB) starting with the inclusion of streptomycin in the first combination therapies. Although parenteral aminog...
In the Caribbean region, the lifetime risk of active tuberculosis (TB) in purified protein derivative (PPD)-positive HIV-infected patients is 50%. Screening of individuals with cough who came to an HIV voluntary counseling and testing center in Haiti revealed active TB in 33% of patients. TB prophylaxis is effective in preventing active disease in HIV-infected individuals, and secondary prophyl...
A simple immunochromatographic assay, Capilia TB, using anti-MPB64 monoclonal antibodies, is a kit for discriminating between the Mycobacterium tuberculosis complex and mycobacteria other than tubercle bacilli. The sensitivity of the kit was estimated to be 99.2% (381 of 384 samples). The sequencing analysis revealed that all of the Capilia TB-negative isolates had mutations within the mpb64 ge...
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