نتایج جستجو برای: proteomics techniques
تعداد نتایج: 656517 فیلتر نتایج به سال:
Since more than a decade proteomics is the method of choice for the life science sector as genetics could not cure all human diseases. Unfortunately, the world of proteins is far more complex than the genome; and a proper analysis can be extremely expensive and time consuming. In addition, the need of standards, standard operation procedures (SOPs) and common rules is obvious. Therefore, the Hu...
Central and South American pitvipers, belonging to the genera Bothrops and Bothriechis, have independently evolved arboreal tendencies. Little is known regarding the composition and activity of their venoms. In order to close this knowledge gap, venom proteomics and toxin activity of species of Bothriechis, and Bothrops (including Bothriopsis) were investigated through established analytical me...
Environmental physiology, toxicology, and ecology and evolution stand to benefit substantially from the relatively recent surge of "omics" technologies into these fields. These approaches, and proteomics in particular, promise to elucidate novel and integrative functional responses of organisms to diverse environmental challenges, over a variety of time scales and at different levels of organiz...
In the early years of proteomics, mass spectrometry served only as a technique in protein chemistry facilitating the characterization of purified proteins and mapping their posttranslational modifications (PTMs). A bit later this technique almost completely replaced Edman degradation and amino acid analysis. The continuous development of the mass spectrometry techniques created a huge analytica...
Microbial communities are the basis for engineered environmental bioprocesses. However, current methods, including 16S rDNA-based techniques, are incapable of providing information on the function of the community or its members, and thus the community remains a black box from a functional perspective. Microbial community proteomics has the potential to detect proteins expressed in an environme...
the present study investigated the effect of the two vocabulary teaching techniques in est, namely the use of translation and the use of visual aids as two separate vocabulary teaching techniques. to answer the question of the study, a pretest (michigan test) was administered to the 58 randomly selected est students at khajeh nasiredin tusi university, faculty of mechanics. after the homogeneit...
This paper describes an approach using information theory to derive a new complexity measure for proteomics maps generated using 2-dimensional gel electrophoresis. The maps used in this study were partitioned into 5x5 grids and the total abundance of protein material in each grid was compared to the total abundance for the entire map. Next, Shannon's relation was applied to characterize the dis...
A powerful interplay exists between the recognition of gene families, sensitive techniques in proteomics, and the interrogation of protein function using chemical probes. The most prominent methods, such as affinity capture, activity-based protein profiling and photoaffinity labeling, are extensively reviewed in the literature. Here we briefly review additional methods developed in the past 15 ...
Despite unmet needs for cardiovascular biomarkers, few new protein markers have been approved by the US Food and Drug Administration for the diagnosis or screening of cardiovascular diseases. Mass spectrometry-based proteomics technologies are capable of identifying hundreds to thousands of proteins in cells, tissues, and biofluids. Proteomics may therefore provide the opportunity to elucidate ...
The vocabulary of proteomics and the swiftly-developing, technological nature of the field constitute substantial barriers to clinical investigators. In recent years, mass spectrometry has emerged as the most promising technique in this field. The purpose of this review is to introduce the field of mass spectrometry-based proteomics to clinical investigators, to explain many of the relevant ter...
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