Quinoxalines display diverse and interesting pharmacological activities as antibacterial, antiviral, antiparasitic and anticancer agents. Particularly, their 1,4-di-N-oxides derivatives have proved to be cytotoxic agents that are active under hypoxic conditions as that of solid tumours. A new series of quinoxaline 1,4-di-N-oxides substitutes at 7-position with esters group were synthetized and ...

Quinoxalines display diverse and interesting pharmacological activities as antibacterial, antiviral, antiparasitic and anticancer agents. Particularly, their 1,4-di-N-oxides derivatives have proved to be cytotoxic agents that are active under hypoxic conditions as that of solid tumours. A new series of quinoxaline 1,4-di-N-oxides substitutes at 7-position with esters group were synthetized and ...

We study several effects that influence the strength of the proton cyclotron and atomic features in the thermal spectra of magnetic neutron stars. We show that it is possible for vacuum polarization to strongly suppress the spectral lines when the magnetic field B & 10 G. For weaker fields (B . 7× 10 G), the surface spectrum is unaffected by vacuum polarization; thus the proton cyclotron absorp...

The basic principles and current status of proton nuclear magnetic resonance imaging are outlined. Nuclear magnetic resonance images of the heart have improved in quality with advances in technique and better gating but clinical experience remains very limited. Myocardial infarction has been shown in animals and man, and plaques of atheroma have been seen with nuclear magnetic resonance flow st...

Evidence for hydrogen bonding between 5'-ribonucleotides in water has been obtained from a 220-MHz proton magnetic resonance study of nitrogenous protons. The amino groups of GMP, AMP, and CMP exhibit proton resonance lines which are somewhat broadened by proton exchange with the solvent at 0 degrees ; their downfield Shifts in mixtures of mononucleotides provide the basis for the following ord...

An increasing number of patients are presenting with central nervous system complications of human immunodeficiency virus infection. New imaging technologies such as magnetic resonance imaging, magnetic resonance proton spectroscopy, single-photon emission computed tomography, and positron emission tomography are playing an ever-increasing role in the diagnosis of these complications. As therap...

We describe a new creatine metabolism disorder in 2 young sisters who suffered from mental retardation and severe language delay. Blood examination, investigation of the most common neurometabolic disorders, and brain magnetic resonance imaging were normal. Diagnosis was established only by means of in vivo proton magnetic resonance spectroscopy, which disclosed generalized depletion of creatin...

Fig 2: Results of quantification with LCModel software. Displayed are: spectrum from healthy tissue (a) and from tumor (b). FIRST PROTON CSI OF A HUMAN BRAIN TUMOR AT 9.4T Grzegorz L. Chadzynski, Sotirios Bisdas, Gisela Hagberg, Rolf Pohmann, G. Shajan, Rupert Kolb, Uwe Klose, and Klaus Scheffler Dept. Biomedical Magnetic Resonance, University Hospital Tuebingen, Tuebingen, Germany, Dept. High-...