INTRODUCTION Proton pump inhibitors (PPIs) have been linked to clinically symptomatic hypomagnesemia. AREAS COVERED We searched Medline database in all languages using 'proton-pump inhibitors, magnesium, hypomagnesemia and hypomagnesemic hypoparathyroidism' as search terms and other articles were identified through searches of the files of the authors and reference lists from relevant article...

Recent findings Several prospective series have reported consistent rates of PPI-REE (30–40%) in adults with suspected EoE. At baseline, PPI-REE and EoE have been shown to be indistinguishable upon clinical, endoscopic, and molecular characteristics [eotaxin-3, interleukin (IL-5), and IL-13 expression]. PPI therapy partially restores esophageal mucosal integrity in PPI-REE, but not in EoE. Anti...

The retinal-protein complex bacteriorhodopsin mediates lightxnergy conversion in halobacteria. This chromoprotein is embedded in the cell membrane and forms insular regions. These can be isolated by membrane-fractionation procedures, and they consist of a lipid matrix containing bacteriorhodopsin molecules in a hexagonal crystalline arrangement called the purple membrane. Light-absorption by ba...

M etformin and proton pump in-hibitors have been implicated in decreasing levels of vitamin B 12 independently. The purpose of this study was to evaluate the effect of concomitant use of metformin and proton pump inhibitors on the incidence of vitamin B 12 deficiency. A retrospective chart review was done using the computerized patient record system at the Memphis VA Medical Center for 614 pati...

BACKGROUND Proton pump inhibitors and histamine H2 receptor antagonists are two of the most commonly prescribed drug classes for pediatric gastroesophageal reflux disease, but their efficacy is controversial. Many patients are treated with these drugs for atypical manifestations attributed to gastroesophageal reflux, even that causal relation is not proven. OBJECTIVE To evaluate the use of pr...

Proton pump inhibitors (PPIs) are among the most commonly prescribed drugs in clinical practice. Since the introduction of these potent acid-suppressing agents in the late 80s, they were listed in the Guinness Book of World Records as the most prescribed in human history. Yet, to be effective in inhibiting the proton pump enzyme (H+/K+ ATPase) in the parietal cells, these drugs should be taken ...

The association between use of proton pump inhibitors and risk of hip fracture was investigated in postmenopausal women. Women who were enrolled in the Nurses’ Health Study, a prospective cohort study, provided data biennially from 2000 until June 2008. The primary outcome was time until first hip fracture. The incidence rate of hip fracture was higher among regular users of proton pump inhibit...

The ba3-type cytochrome c oxidase from Thermus thermophilus is a membrane-bound protein complex that couples electron transfer to O2 to proton translocation across the membrane. To elucidate the mechanism of the redox-driven proton pumping, we investigated the kinetics of electron and proton transfer in a structural variant of the ba3 oxidase where a putative "pump site" was modified by replace...

Objective: To discuss the role of a proton pump inhibitor (pantoprazole) as a cause of night sweats in an older person. Methods: Our case involves a 73 year-old man who experienced night sweats while taking pantoprazole to treat gastroesophageal reflux disease. Results: Night sweats disappeared ten days after ceasing pantoprazole. They recurred two months later, one week after recommencing pant...

E vidence is accumulating in relation to adverse events associated with proton pump inhibitors (PPIs). Reports in the Archives have demonstrated an association with fractures, Clostridium difficile infections, and community-acquired pneumonia. Proton pump inhibitors may also attenuate the antiplatelet benefits of clopidogrel. Because frail older people often use PPIs and may be especially vulne...