A surgical approach is described that has been used in nearly 200 primary cases of Dupuytren's disease treated by one surgeon. Special attention and comments are directed to the proximal interphalangeal joint, a notoriously difficult area to correct. Observations suggest that the pathologic anatomy of this area is more variable and complex than generally described. The importance of postoperati...

OBJECTIVE Heberden's nodes are often used as a marker for osteoarthritis (OA). This study examined how often Heberden's nodes and radiological distal interphalangeal (DIP) osteophytes coexist in the same digit and the sensitivity, specificity, and positive predicative value of each for OA at different sites or generalised disease. METHODS This was a population-based study of 660 middle ages w...

Gradient sensing, polarization, and chemotaxis of motile cells involve the actin cytoskeleton, and regulatory modules, including the phosphoinositides (PIs), their kinases/phosphatases, and small GTPases (Rho proteins). Here we model their individual components (PIP1, PIP2, PIP3; PTEN, PI3K, PI5K; Cdc42, Rac, Rho; Arp2/3, and actin), their interconversions, interactions, and modular functions i...

ION CHANNEL MODULATION BY PHOTOCAGED DIOCTANOYL PIP2 by Junghoon Ha, BSc. A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science at Virginia Commonwealth University. Virginia Commonwealth University, 2009 Thesis Director: Diomedes E. Logothetis, Ph.D. Chair, Department of Physiology and Biophysics Phosphatidylinositol bisphosphate (PIP2) directly regul...

The phosphatidylinositol pathway is implicated in the regulation of numerous cellular functions and responses to extracellular signals. An important branching point in the pathway is the phosphorylation of phosphatidylinositol 4-phosphate by the phosphatidylinositol 4-phosphate 5-kinase (PIP5K) to generate the second messenger phosphatidylinositol 4,5-bis-phosphate (PIP2). PIP5K and PIP2 have b...

The Americanjoumal a/Occupational Therapy T he proXimal interphalangeal (PIP) joint is particularly susceptible to acute ligamentous injury, and such an injury can result in swelling without ligament laXity, collateral ligament laXity and disruption, or a partial or complete avulsion of the volar plate with or without bony involvement. Many articles have been written about methods for treatment...

BACKGROUND Dynamic joint motion recording combined with CT-based 3D bone and joint surface data is accepted as a helpful and precise tool to analyse joint. The purpose of this study is to demonstrate the feasibility of these techniques for quantitative motion analysis of the interphalangeal joint in 3D. MATERIALS AND METHOD High resolution motion data was combined with an accurate 3D model of...

Prosthetic replacement of the proximal interphalangeal joints is an operative treatment for osteoarhtritis, to preserve the range of motion and the function of the hand. The purpose of this study is to detect the differences regarding pain and function between a silicone implant using a volar approach and a resurfacing implant, placed through a dorsal approach. Patients were reviewed clinically...

Pain, stiffness, instability and degenerative arthritis are common sequelae of complex fracture-dislocations of the proximal interphalangeal (PIP) joint. Operations were carried out to obtain stability, followed by application of a dynamic external fixator in 20 patients with a mean age of 29 years. This provided stability and distraction, and allowed controlled passive movement. Most (70%) of ...

DESCRIPTION A 51-year-old woman presented to the emergency department after sustaining a transverse volar laceration over the middle phalanx of her right small finger. On physical examination, the patient was unable to flex her finger at the proximal or distal interphalangeal joint.