Methods: Review of the evidence for safety, acceptability and efficacy of PRP in decreasing pain and improving healing and function in players with musculoskeletal injuries. A case study of post-PRP rehabilitation in professional football and qualitative data regarding players’ understanding of PRP, tolerability and effect is presented. The case study examines the rehabilitation protocol post-P...

Background: Platelet-rich plasma (PRP) has long been known as an effective treatment in various surgical and medical fields. Face and neck revitalization with PRP is an application that is currently being explored. The aim of this paper is practical: to evaluate if there are real outcomes, benefits and side effects of a standardized injection protocol in a continuous series, without control gro...

Platelet-rich plasma (PRP), a blood derivative with high concentrations of platelets, has been found to have high levels of autologous growth factors (GFs), such as transforming growth factor-β (TGF-β), platelet-derived growth factor (PDGF), fibroblastic growth factor (FGF), vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF). These GFs and other biological active prote...

INTRODUCTION Knee osteoarthritis is a very common chronic degenerative disease that could impose significant costs to the health system. Although osteoarthritis can affect all joints, knee osteoarthritis is the most common type among adolescents. Non-surgical treatments include corticosteroids injection, hyaluronic acid, and platelet-rich plasma. The aim of this study was to investigate the eff...

UNLABELLED The platelet-rich plasma (PRP) is an autologous biotherapy commonly used for its healing properties. Once activated, platelets released a real "cocktail" of growth factor and cytokines implied in numerous regenerative processes. However the impact of medical practices associated to PRP therapeutic use on platelets functionality remains poorly known. OBJECTIVES we evaluated the in v...

Platelet-rich plasma (PRP) is emerging as a biological therapy for the treatment of cartilage injuries and for intra-articular application to address knee pain. Basic science studies indicate that PRP stimulates cell proliferation and the production of cartilage matrix by chondrocytes and bone marrow–derived mesenchymal stromal cells and increases the production of hyaluronic acid by synoviocyt...

The prion hypothesis posits that a misfolded form of prion protein (PrP) is responsible for the infectivity of prion disease. Using recombinant murine PrP purified from Escherichia coli, we created a recombinant prion with the attributes of the pathogenic PrP isoform: aggregated, protease-resistant, and self-perpetuating. After intracerebral injection of the recombinant prion, wild-type mice de...

OBJECTIVE To evaluate intravitreal injection of triamcinolone acetonide before laser panretinal photocoagulation (PRP) in the treatment of proliferative diabetic retinopathy. METHODS This interventional case series included 9 patients with bilateral proliferative diabetic retinopathy. One eye received intravitreal triamcinolone before PRP (injected eye) and the other, PRP alone (control eye)....

Platelet-rich plasma (PRP) has been of great concern to the scientists and doctors who are involved in wound healing and regenerative medicine which focuses on repairing and replacing damaged cells and tissues. Growth factors of platelet-rich plasma are cost-effective, available, and is more stable than recombinant human growth factors. Given these valuable properties, we decided to assess the ...

The aim of the study was a comparative evaluation bone marrow aspirate concentrate (BMAC) and platelet-rich plasma (PRP), administered intraosseously to patients with stage IIIII knee osteoarthritis (OA) according Kellgren Lawrence (K-L) classification. Materials methods: 40 were recruited divided into 2 groups for multicenter randomized study. Patients in main group (n = 19) underwent single i...