The presence of acetone-soluble renin inhibitors in normal plasma has been proposed to explain the variation of plasma reactivity (PRR) in samples from normotensive and hypertensive subjects. In our experience, acetone extraction decreased PRR in relation to unextracted control values, an observation which is not consistent with the circulating lipid-renin inhibitor hypothesis. Exposure to acet...

Previous studies have indicated that hyperactivity of brain prorenin receptors (PRR) is implicated in neurogenic hypertension. However, the role of brain PRR in regulating arterial blood pressure (ABP) is not well understood. Here, we test the hypothesis that PRR activation in the hypothalamic paraventricular nucleus (PVN) contributes to increased sympathetic nerve activity (SNA). In anaestheti...

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(Pro)renin receptor (PRR) is the recently discovered component of renin-angiotensin-aldosterone system (RAS). Many organs contain their own RAS, wherein PRR can exert organ-specific localized effects. The Binding prorenin/renin to activates angiotensin-dependent and independent pathways which leads development physiological pathological Continued progress in research suggests that upregulation ...

Microbial and plant cell walls have been selected by the immune system as a source of microbe- damage-associated molecular patterns (MAMPs/DAMPs) that are perceived extracellular ectodomains (ECDs) pattern recognition receptors (PRRs) triggering responses. From vast number ligands PRRs can bind, those composed carbohydrate moieties poorly studied, only handful PRR/glycan pairs determined. Here ...

PURPOSE MicroRNAs (miRNAs/miRs) are involved in a large number of biological functions and diseases, such as cancer, cardiovascular diseases, and diabetes. MiR-21 has been reported to target Sprouty homolog 1 (SPRY1), SMAD7, and PTEN. In this study, we examined the underlying role of miR-21 in the regulation of prorenin receptor (PRR)-mediated induction of vascular endothelial growth factor (VE...

The host immune response is initiated by pattern recognition receptors (PRR) when triggered by specific ligands known as pathogen-associated molecular patterns (PAMP). Toll-like receptor 9 is highly expressed in plasmacytoid dendritic cells and is well described as a PRR for CpG DNA which induce the production of cytokines and type I interferons. In this issue of The EMBO Journal, Rigby et al i...

Over the last decade, invasive fungal infections have emerged as a growing threat to human health worldwide and novel treatment strategies are urgently needed. In this context, investigations into host-pathogen interactions represent an important and promising field of research. Antigen presenting cells such as macrophages and dendritic cells are strategically located at the frontline of defenc...

The human body is constantly challenged by a variety of commensal and pathogenic microorganisms that trigger the immune system. Central in the first line of defence is the patternrecognition receptor (PRR)-induced stimulation of the NFkB pathway, leading to NFkB activation. The subsequent production of pro-inflammatory cytokines and/or antimicrobial peptides results in recruitment of profession...