Efficient gene delivery in the central nervous system (CNS) is important in studying gene functions, modeling neurological diseases and developing therapeutic approaches. Lentiviral vectors are attractive tools in transduction of neurons and other cell types in CNS as they transduce both dividing and non-dividing cells, support sustained expression of transgenes, and have relatively large packa...

genes are literally shot into plant cells) and a variant, particle discharge (Birch, 1997). Several claims have been made about genetic engineering (GE) GE has now reached the commercial stage. New cultiin comparison with crop domestication and classical plant breeding, including the similarity of genetic changes between those taking place vars of maize (Zea mays L.), soybean [Glycine max (L.) ...

HomePlant DiseaseVol. 106, No. 1First Report of Pectobacterium versatile Causing Blackleg Potato in Serbia PreviousNext DISEASE NOTE OPENOpen Access licenseFirst SerbiaSanja Markovi?, Sonja Mili? Komi?, Aleksandra Jeluši?, Renata Ili?i?, Ferenc Bagi, Slaviša Stankovi?, and Tatjana Popovi?Sanja Markovi?University Belgrade, Institute for Multidisciplinary Research, Belgrade 11030, SerbiaSearch mo...

Membrane-anchored forms of the v-sis oncoprotein have been previously described which are oriented as type I transmembrane proteins and which efficiently induce autocrine transformation. Several examples of naturally occurring membrane-anchored growth factors have been identified, but all exhibit a type I orientation. In this work, we wished to construct and characterize membrane-anchored growt...

Nuclear factor B (NFB) activated by tumor necrosis factor (TNF) attenuates the TNF-induced apoptosis pathway. Therefore, blockage of NFB should improve the anticancer activity of TNF. Luteolin, a naturally occurring polyphenol flavonoid, has been reported to sensitize colorectal cancer cells to TNF-induced apoptosis through suppression of NFB; however, the mechanisms of this effect have not bee...

UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1) catalyzes the glucuronidation of bilirubin in liver. Among all UGT isoforms identified to date, it is the only relevant bilirubin-glucuronidating enzyme in human. Because glucuronoconjugation is the major route of bilirubin elimination, any genetic alteration that affects bilirubin glucuronosyltransferase activity may result in a more or less sever...

UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1) catalyzes the glucuronidation of bilirubin in liver. Among all UGT isoforms identified to date, it is the only relevant bilirubin-glucuronidating enzyme in human. Because glucuronoconjugation is the major route of bilirubin elimination, any genetic alteration that affects bilirubin glucuronosyltransferase activity may result in a more or less sever...