We report on an iconoclastic strategy for inhibiting proteases via autolysis acceleration. We show that proteases can be concentrated and induced to rapidly self-digest by a biocompatible polymer serving as an efficient catalyst. This new generation of protease inhibitors may find applications in the treatment of various protease-dependent diseases.

Abstract This article focuses on W.E.B. Du Bois’s ambivalent reception of Protestantism, and religion in general. It argues that he rejected institutional Protestantism as characterized by cold formalism, but thought the teaching practices this taking place Negro Churches were still relevant to most American Blacks. As pointed out some secondary literature, Bois maintained religious institution...

BACKGROUND Alpha-lactalbumin (α-LA) is a calcium-bound mammary gland-specific protein that is found in milk. This protein is a modulator of β1,4-galactosyltransferase enzyme, changing its acceptor specificity from N-acetyl-glucosamine to glucose, to produce lactose, milk's main carbohydrate. When calcium is removed from α-LA, it adopts a molten globule form, and this form, interestingly, when c...

This article compares the books about Lifes of Thomas More written by Roper and Harpsfield work Tomás Moro Fernando de Herrera. The comparison is taken as a case in point divergent early development biographical genre England Spain. three texts were Catholic humanists, but under different contexts, which produced kinds text. Roper’s Harpsfield’s Catholicism, marked close contact with Morean tra...

^ This little book is one of extraordinary interest. In fact, may be described as almost sensational in its iconoclastic velty. its distinguished author proves by a series of simple Periments that the commonly accepted teaching about the ? ?wth and vitality of bone depending upon the periosteum quite fallacious. tt is shown how when a sub-periosteal resection of bone is ?e> no new bone is forme...

While everyone knows that we should eat healthily, translating such information into practice is a major challenge for many of us when it comes to eating well. So despite a huge increase in awareness of the implications of food-choices, obesity levels in the UK continue to increase. In this paper, we present a novel application designed to deliver psychological ‘Approach Avoidance’ training in ...

If Hamlet had not delayed his revenge there would have been no play. Many explanations of the delay have been offered in the last four centuries. None is convincing. The interpretation which best fits the evidence best is that Hamlet was suffering from an acute depressive illness, with some obsessional features. He could not make a firm resolve to act. In Shakespeare's time there was no concept...

Modern industrial processes require advanced computer tools that should adapt to the user requirements and to the tasks being solved. Strategy learning consists of automating the acquisition of patterns of actions used while solving particular tasks. Current intelligent strategy learning systems acquire operational knowledge to improve the eeciency of a particular problem solver. However, these...

Many games and simulations utilize modularized low-level code to move characters about in an environment. This requires extensive technical skill to translate basic high-level actions, as well as extensive time to write code, which includes very detailed instructions on what and when actions will occur across all agents. Other options exist such as mocap files; however, most are not highly dyna...

NEARLY EVERYONE would see the truth as between Hamlet and Puck. Including Hamlet and Puck. Hamlet is feigning madness, and Puck is just being, well, puckish. Model-writing economists, however, tend not to the middle but to the “infinite in faculties” extreme. Although the postulate of unbounded rationality has dominated economic modeling for several decades, the dominance is relaxing. Is this e...