In the title compound, C(25)H(30)O(6), the two fused cyclo-hexa-none rings have envelope conformations, whereas the central pyran ring is roughly planar [mximum deviation = 0.045 (2) Å]. The pyran and benzene rings are almost perpendicular to each other, making a dihedral angle of 86.32 (2)°. In the crystal, molecules are linked via pairs of O-H⋯O hydrogen bonds, forming inversion dimers.

Pharmaceutical chemistry is focused on quality aspects of medicines and aims to assure fitness for the purpose medicinal products. With centuries had emerged as a magnanimous field science getting facelift from available natural compounds synthesis newer complex molecules possessing activity while transit earth synthetically furnished laboratory. Medicinal or pharmaceutical discipline at inters...

Cyclopenta-, benzo-, and cyclohepta[b]-annulated azepane scaffolds were prepared in two steps from optically active cyclic α-allyl-β-oxoesters. The first step was ruthenium-catalyzed olefin cross metathesis with acrylonitrile. second palladium-catalyzed dihydrogenation which consists of three consecutive processes: hydrogenation the C−C double C−N triple bonds followed by reductive amination vi...

In the title compound, C(15)H(11)N(3)O(4)S, the dihedral angle between the mean planes of the dihydro-indol-2-one (r.m.s. deviation = 0.015 Å) and dihydro-thieno[3,2-b]pyran (r.m.s. deviation = 0.011 Å) ring systems is 89.53 (3)°. The crytal packing is consolidated by inter-molecular N-H⋯O and N-H⋯N hydrogen bonds, which link the mol-ecules into a two-dimensional network into sheets lying paral...

The main structural unit of the title compoud, C(21)H(18)O(6), is a fused three-ring group consisting of coumarin and tetra-hydro-pyrane ring systems. Two C atoms of the tetra-hydro-pyran ring are displaced by 0.295 (3) and -0.360 (2) Å from the mean plane of coumarin ring. The dihedral angle between the phenyl and coumarin rings is 73.94 (3)°. Inter-molecular O-H⋯O hydrogen bonds are present i...

In the title compound, C(25)H(22)ClNO(3)S, both the pyrrolidinyl and thia-zolyl rings adopt envelope conformations whereas the dihydro-pyran ring adopts a half-chair conformation. The chloro-phenyl and naphthalenyl ring systems are oriented at a dihedral angle of 59.7 (1)°. The crystal packing is stabilized by an intra-molecular C-H⋯N hydrogen bond and weak inter-molecular C-H⋯π inter-actions.

Two benzothiadiazole derivatives annulated with 2-(1,3-dithiol-2-ylidene)malonitrile in the 4,5-position were prepared by a one-step procedure, and investigated as end-groups non-fullerene acceptors for indoor photovoltaic applications.

Homoconjugation is a phenomenon discussed for various ?-systems where classical conjugation broken by e.g. methylene units but still stabilization electronic communication exists. In this respect, triptycene with its rigid C3 symmetric geometry an ideal scaffold to study phenomenon. Although several studies based on strengthen the hypothesis of homoconjugation, in all described cases through sp...

THE TITLE COMPOUND (SYSTEMATIC NAME 7-oxo-3-phenyl-2,6-dioxabicyclo-[3.3.1]nonan-4-yl acetate), C(15)H(16)O(5), is a styryllactone derivative which was isolated from Goniothalamus macrophyllus. The mol-ecule has two fused rings consisting of a tetra-hydro-2H-pyran and a lactone ring, with the benzene ring and the acetyl group attached to the tetra-hydro-2H-pyran ring. The tetra-hydro-2H-pyran r...

The duration of protection afforded by 5 known interferon inducers was deterw•ined. Groups of mice were given a single dose of statolon, maleic acid-divinyl ether copolymer (pyran), polycytidylic/polyinosinic acid (I/C), Newcastle disease virus (NDV), or bacterial endotoxin. These groups and an untrek,3d control group were uniformly challenged with MM virus. Survival data obtained during 20 day...